Version 5.4
Homo sapiens Protein: SLC47A2
Summary
InnateDB Protein IDBP-34912.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SLC47A2
Protein Name solute carrier family 47, member 2
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000326671
InnateDB Gene IDBG-34910 (SLC47A2)
Protein Structure
UniProt Annotation
Function Solute transporter for tetraethylammonium (TEA), 1- methyl-4-phenylpyridinium (MPP), cimetidine, N-methylnicotinamide, metformin, creatinine, guanidine, procainamide, topotecan, estrone sulfate, acyclovir, and ganciclovir. Responsible for the secretion of cationic drugs across the brush border membranes. {ECO:0000269PubMed:16807400, ECO:0000269PubMed:16996621, ECO:0000269PubMed:17509534}.
Subcellular Localization Cell membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. Note=Localized at the brush border membranes of the proximal tubules.
Disease Associations
Tissue Specificity Isoform 3 is predominantly expressed in kidney. Isoform 6 is expressed in brain. {ECO:0000269PubMed:16807400}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0015238 drug transmembrane transporter activity
GO:0015297 antiporter activity
Biological Process
GO:0006855 drug transmembrane transport
GO:0055085 transmembrane transport
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID
InterPro IPR002528 Multi antimicrobial extrusion protein
PFAM PF01554
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q86VL8
PhosphoSite PhosphoSite-Q86VL8
TrEMBL
UniProt Splice Variant
Entrez Gene 146802
UniGene Hs.126830
RefSeq NP_690872
HUGO HGNC:26439
OMIM 609833
CCDS CCDS11211
HPRD 08710
IMGT
EMBL AB250364 AB250701 AK055758 BC035288 BC050578 BX648861 CH471212
GenPept AAH35288 AAH50578 BAF36847 BAF37007 CAH56154 EAW50902 EAW50904 EAW50905

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca