InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: APEH

Summary

InnateDB Protein

IDBP-34957.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

APEH

Protein Name

N-acylaminoacyl-peptide hydrolase

Synonyms

AARE; ACPH; APH; D3F15S2; D3S48E; DNF15S2; OPH;

Species

Homo sapiens

Ensembl Protein

ENSP00000296456

InnateDB Gene

IDBG-34955 (APEH)

Protein Structure

UniProt Annotation

Function

This enzyme catalyzes the hydrolysis of the N-terminal peptide bond of an N-acetylated peptide to generate an N- acetylated amino acid and a peptide with a free N-terminus. It preferentially cleaves off Ac-Ala, Ac-Met and Ac-Ser. {ECO:0000269PubMed:1861871, ECO:0000269PubMed:2006156}.

Subcellular Localization

Cytoplasm.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 36 experimentally validated interaction(s) in this database.

Experimentally validated
Total	36 [view]
Protein-Protein	34 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004252	serine-type endopeptidase activity
GO:0008236	serine-type peptidase activity
GO:0008242	omega peptidase activity
GO:0016787	hydrolase activity
GO:0044822	poly(A) RNA binding

Biological Process

GO:0006508	proteolysis
GO:0050435	beta-amyloid metabolic process

Cellular Component

GO:0005737	cytoplasm
GO:0031965	nuclear membrane
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

InterPro

IPR000073 Alpha/beta hydrolase fold-1
IPR001375 Peptidase S9, prolyl oligopeptidase, catalytic domain
IPR002925 Dienelactone hydrolase
IPR029058 Alpha/Beta hydrolase fold

PFAM

PF00561
PF00326
PF01738

PRINTS

PR00111

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P13798