Homo sapiens Gene: APEH
Summary
InnateDB Gene IDBG-34955.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol APEH
Gene Name N-acylaminoacyl-peptide hydrolase
Synonyms AARE; ACPH; APH; D3F15S2; D3S48E; DNF15S2; OPH
Species Homo sapiens
Ensembl Gene ENSG00000164062
Encoded Proteins
N-acylaminoacyl-peptide hydrolase
N-acylaminoacyl-peptide hydrolase
N-acylaminoacyl-peptide hydrolase
N-acylaminoacyl-peptide hydrolase
N-acylaminoacyl-peptide hydrolase
N-acylaminoacyl-peptide hydrolase
N-acylaminoacyl-peptide hydrolase
N-acylaminoacyl-peptide hydrolase
N-acylaminoacyl-peptide hydrolase
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes the enzyme acylpeptide hydrolase, which catalyzes the hydrolysis of the terminal acetylated amino acid preferentially from small acetylated peptides. The acetyl amino acid formed by this hydrolase is further processed to acetate and a free amino acid by an aminoacylase. This gene is located within the same region of chromosome 3 (3p21) as the aminoacylase gene, and deletions at this locus are also associated with a decrease in aminoacylase activity. The acylpeptide hydrolase is a homotetrameric protein of 300 kDa with each subunit consisting of 732 amino acid residues. It can play an important role in destroying oxidatively damaged proteins in living cells. Deletions of this gene locus are found in various types of carcinomas, including small cell lung carcinoma and renal cell carcinoma. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 3:49674002-49683963
Strand Forward strand
Band p21.31
Transcripts
ENST00000296456 ENSP00000296456
ENST00000449966 ENSP00000414369
ENST00000446089 ENSP00000410149
ENST00000438011 ENSP00000415862
ENST00000442186 ENSP00000402365
ENST00000447436 ENSP00000401871
ENST00000457042 ENSP00000410366
ENST00000447541 ENSP00000404353
ENST00000483715
ENST00000491799
ENST00000463995
ENST00000462439
ENST00000463616
ENST00000482301
ENST00000469362 ENSP00000438180
ENST00000480772
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 36 experimentally validated interaction(s) in this database.
Experimentally validated
Total 36 [view]
Protein-Protein 34 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004252 serine-type endopeptidase activity
GO:0008236 serine-type peptidase activity
GO:0008242 omega peptidase activity
GO:0016787 hydrolase activity
GO:0044822 poly(A) RNA binding
Biological Process
GO:0006508 proteolysis
GO:0050435 beta-amyloid metabolic process
Cellular Component
GO:0005737 cytoplasm
GO:0031965 nuclear membrane
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.517969
RefSeq NM_001640 XM_005265098
HUGO
OMIM
CCDS CCDS2801
HPRD 00034
IMGT
EMBL
GenPept
RNA Seq Atlas