InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ULK2

Summary

InnateDB Protein

IDBP-35100.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ULK2

Protein Name

unc-51-like kinase 2 (C. elegans)

Synonyms

ATG1B; Unc51.2;

Species

Homo sapiens

Ensembl Protein

ENSP00000354877

InnateDB Gene

IDBG-35098 (ULK2)

Protein Structure

UniProt Annotation

Function

Serine/threonine-protein kinase involved in autophagy in response to starvation. Acts upstream of phosphatidylinositol 3- kinase PIK3C3 to regulate the formation of autophagophores, the precursors of autophagosomes. Part of regulatory feedback loops in autophagy: acts both as a downstream effector and a negative regulator of mammalian target of rapamycin complex 1 (mTORC1) via interaction with RPTOR. Activated via phosphorylation by AMPK, also acts as a negative regulator of AMPK through phosphorylation of the AMPK subunits PRKAA1, PRKAB2 and PRKAG1. May phosphorylate ATG13/KIAA0652, FRS2, FRS3 and RPTOR; however such data need additional evidences. Not involved in ammonia-induced autophagy or in autophagic response of cerebellar granule neurons (CGN) to low potassium concentration. Plays a role early in neuronal differentiation and is required for granule cell axon formation: may govern axon formation via Ras-like GTPase signaling and through regulation of the Rab5-mediated endocytic pathways within developing axons. {ECO:0000269PubMed:18936157, ECO:0000269PubMed:21460634, ECO:0000269PubMed:21460635, ECO:0000269PubMed:21690395, ECO:0000269PubMed:21795849}.

Subcellular Localization

Cytoplasmic vesicle membrane {ECO:0000269PubMed:18936157}; Peripheral membrane protein {ECO:0000269PubMed:18936157}. Note=Localizes to pre- autophagosomal membrane.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 19 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	19 [view]
Protein-Protein	18 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003824	catalytic activity
GO:0004672	protein kinase activity
GO:0004674	protein serine/threonine kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0016773	phosphotransferase activity, alcohol group as acceptor

Biological Process

GO:0000045	autophagic vacuole assembly
GO:0006468	protein phosphorylation
GO:0007165	signal transduction
GO:0007409	axonogenesis
GO:0009103	lipopolysaccharide biosynthetic process
GO:0010506	regulation of autophagy
GO:0042594	response to starvation
GO:0046777	protein autophosphorylation
GO:0048675	axon extension

Cellular Component

GO:0005829	cytosol
GO:0016020	membrane
GO:0030659	cytoplasmic vesicle membrane
GO:0034045	pre-autophagosomal structure membrane
GO:0034273	ATG1/UKL1 signaling complex

Protein Structure and Domains

PDB ID

InterPro

IPR000719 Protein kinase domain
IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
IPR002290 Serine/threonine/dual specificity protein kinase, catalytic domain
IPR010440 Lipopolysaccharide kinase
IPR011009 Protein kinase-like domain
IPR016237 Serine/threonine-protein kinase, Ulk1/Ulk2
IPR018934 RIO-like kinase
IPR020635 Tyrosine-protein kinase, catalytic domain
IPR022708 Serine/threonine-protein kinase, C-terminal

PFAM

PF00069
PF07714
PF06293
PF01163
PF12063

PRINTS

PR00109

PIRSF

PIRSF000580

SMART

SM00220
SM00219

TIGRFAMs

Post-translational Modifications

Modification

Cross-References