InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: ULK2

Summary

InnateDB Gene

IDBG-35098.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ULK2

Gene Name

unc-51-like kinase 2 (C. elegans)

Synonyms

ATG1B; Unc51.2

Species

Homo sapiens

Ensembl Gene

ENSG00000083290

Encoded Proteins

IDBP-35100

unc-51-like kinase 2 (C. elegans)

IDBP-239324

unc-51-like kinase 2 (C. elegans)

IDBP-762566

IDBP-758724

IDBP-764084

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes a protein that is similar to a serine/threonine kinase in C. elegans which is involved in axonal elongation. The structure of this protein is similar to the C. elegans protein in that both proteins have an N-terminal kinase domain, a central proline/serine rich (PS) domain, and a C-terminal (C) domain. The gene is located within the Smith-Magenis syndrome region on chromosome 17. Alternatively spliced transcript variants encoding the same protein have been identified. [provided by RefSeq, Dec 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 17:19770829-19867936

Strand

Reverse strand

Band

p11.2

Transcripts

ENST00000361658	ENSP00000354877
ENST00000395544	ENSP00000378914
ENST00000575432	ENSP00000464892
ENST00000571137
ENST00000570983
ENST00000574854
ENST00000571177
ENST00000580118	ENSP00000467277
ENST00000580130
ENST00000571454
ENST00000574732	ENSP00000465666

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 19 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	19 [view]
Protein-Protein	18 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003824	catalytic activity
GO:0004672	protein kinase activity
GO:0004674	protein serine/threonine kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0016773	phosphotransferase activity, alcohol group as acceptor

Biological Process

GO:0000045	autophagic vacuole assembly
GO:0006468	protein phosphorylation
GO:0007165	signal transduction
GO:0007409	axonogenesis
GO:0009103	lipopolysaccharide biosynthetic process
GO:0010506	regulation of autophagy
GO:0042594	response to starvation
GO:0046777	protein autophosphorylation
GO:0048671	negative regulation of collateral sprouting
GO:0048675	axon extension

Cellular Component

GO:0005829	cytosol
GO:0016020	membrane
GO:0030659	cytoplasmic vesicle membrane
GO:0034045	pre-autophagosomal structure membrane
GO:0034273	ATG1/UKL1 signaling complex

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000004798

View Gene Order

ENSBTAG00000030977

Not yet available

Pathways

NETPATH

REACTOME

KEGG

hsa04150

mTOR signaling pathway pathway

hsa04140

Regulation of autophagy pathway

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Hs.168762 Hs.609191

RefSeq

NM_001142610 NM_014683

HUGO

OMIM

CCDS

CCDS11213

HPRD

10556

IMGT

EMBL

GenPept

RNA Seq Atlas