Version 5.4
Homo sapiens Protein: RNF123
Summary
InnateDB Protein IDBP-35203.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol RNF123
Protein Name ring finger protein 123
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000328287
InnateDB Gene IDBG-35201 (RNF123)
Protein Structure
UniProt Annotation
Function Catalytic subunit of the KPC complex that acts as E3 ubiquitin-protein ligase. Required for poly-ubiquitination and proteasome-mediated degradation of CDKN1B during G1 phase of the cell cycle. {ECO:0000269PubMed:15531880, ECO:0000269PubMed:16227581}.
Subcellular Localization Cytoplasm {ECO:0000269PubMed:15531880}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 17 experimentally validated interaction(s) in this database.
They are also associated with 11 interaction(s) predicted by orthology.
Experimentally validated
Total 17 [view]
Protein-Protein 17 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 11 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0016874 ligase activity
Biological Process
GO:0016567 protein ubiquitination
Cellular Component
GO:0005737 cytoplasm
Protein Structure and Domains
PDB ID
InterPro IPR001841 Zinc finger, RING-type
IPR001870 B30.2/SPRY domain
IPR003877 SPRY domain
IPR008985 Concanavalin A-like lectin/glucanases superfamily
PFAM PF13639
PF14634
PF00622
PRINTS
PIRSF
SMART SM00184
SM00449
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q5XPI4
PhosphoSite PhosphoSite-Q5XPI4
TrEMBL C9JN91
UniProt Splice Variant
Entrez Gene 63891
UniGene Hs.741120
RefSeq NP_071347
HUGO HGNC:21148
OMIM 614472
CCDS CCDS33758
HPRD 11499
IMGT
EMBL AC099668 AF370367 AK022627 AK026968 AL136729 AY744152 BC041145 BC057392 BC088801 BC130632
GenPept AAH41145 AAH57392 AAH88801 AAI30633 AAQ15203 AAU93470 BAB14139 BAB15607 CAB66663

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca