InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: UGT8

Summary

InnateDB Protein

IDBP-35212.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

UGT8

Protein Name

UDP glycosyltransferase 8

Synonyms

CGT; UGT4;

Species

Homo sapiens

Ensembl Protein

ENSP00000311648

InnateDB Gene

IDBG-35210 (UGT8)

Protein Structure

UniProt Annotation

Function

Catalyzes the transfer of galactose to ceramide, a key enzymatic step in the biosynthesis of galactocerebrosides, which are abundant sphingolipids of the myelin membrane of the central nervous system and peripheral nervous system.

Subcellular Localization

Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003851	2-hydroxyacylsphingosine 1-beta-galactosyltransferase activity
GO:0008489	UDP-galactose:glucosylceramide beta-1,4-galactosyltransferase activity
GO:0016758	transferase activity, transferring hexosyl groups
GO:0030246	carbohydrate binding

Biological Process

GO:0002175	protein localization to paranode region of axon
GO:0005975	carbohydrate metabolic process
GO:0006682	galactosylceramide biosynthetic process
GO:0007010	cytoskeleton organization
GO:0007417	central nervous system development
GO:0007422	peripheral nervous system development
GO:0008088	axon cargo transport
GO:0008152	metabolic process
GO:0030259	lipid glycosylation
GO:0030913	paranodal junction assembly
GO:0048812	neuron projection morphogenesis