Version 5.4
Homo sapiens Gene: UGT8
Summary
InnateDB Gene IDBG-35210.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol UGT8
Gene Name UDP glycosyltransferase 8
Synonyms CGT; UGT4
Species Homo sapiens
Ensembl Gene ENSG00000174607
Encoded Proteins
IDBP-35212
UDP glycosyltransferase 8
IDBP-241448
UDP glycosyltransferase 8
IDBP-479009
UDP glycosyltransferase 8
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene belongs to the UDP-glycosyltransferase family. It catalyzes the transfer of galactose to ceramide, a key enzymatic step in the biosynthesis of galactocerebrosides, which are abundant sphingolipids of the myelin membrane of the central and peripheral nervous systems. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Sep 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 4:114598455-114678224
Strand Forward strand
Band q26
Transcripts
ENST00000310836 ENSP00000311648
ENST00000394511 ENSP00000378019
ENST00000507710 ENSP00000421446
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003851 2-hydroxyacylsphingosine 1-beta-galactosyltransferase activity
GO:0008489 UDP-galactose:glucosylceramide beta-1,4-galactosyltransferase activity
GO:0016758 transferase activity, transferring hexosyl groups
GO:0030246 carbohydrate binding
Biological Process
GO:0002175 protein localization to paranode region of axon
GO:0005975 carbohydrate metabolic process
GO:0006682 galactosylceramide biosynthetic process
GO:0007010 cytoskeleton organization
GO:0007417 central nervous system development
GO:0007422 peripheral nervous system development
GO:0008088 axon cargo transport
GO:0008152 metabolic process
GO:0030259 lipid glycosylation
GO:0030913 paranodal junction assembly
GO:0048812 neuron projection morphogenesis
Cellular Component
GO:0016021 integral component of membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000032854
View Gene Order
ENSBTAG00000004574
Not yet available
Pathways
NETPATH
REACTOME
KEGG
hsa00600
Sphingolipid metabolism pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.144197 Hs.743468
RefSeq NM_001128174 NM_003360 XM_006714303
HUGO
OMIM
CCDS CCDS3705
HPRD 03186
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca