InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: KRT18

Summary

InnateDB Protein

IDBP-35303.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

KRT18

Protein Name

keratin 18

Synonyms

CYK18; K18;

Species

Homo sapiens

Ensembl Protein

ENSP00000373487

InnateDB Gene

IDBG-35299 (KRT18)

Protein Structure

UniProt Annotation

Function

Involved in the uptake of thrombin-antithrombin complexes by hepatic cells (By similarity). When phosphorylated, plays a role in filament reorganization. Involved in the delivery of mutated CFTR to the plasma membrane. Together with KRT8, is involved in interleukin-6 (IL-6)-mediated barrier protection. {ECO:0000250, ECO:0000269PubMed:15529338, ECO:0000269PubMed:16424149, ECO:0000269PubMed:17213200, ECO:0000269PubMed:7523419, ECO:0000269PubMed:8522591, ECO:0000269PubMed:9298992, ECO:0000269PubMed:9524113}.

Subcellular Localization

Cytoplasm, perinuclear region. Nucleus, nucleolus.

Disease Associations

Cirrhosis (CIRRH) [MIM:215600]: A liver disease characterized by severe panlobular liver-cell swelling with Mallory body formation, prominent pericellular fibrosis, and marked deposits of copper. Clinical features include abdomen swelling, jaundice and pulmonary hypertension. {ECO:0000269PubMed:12724528, ECO:0000269PubMed:9011570}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Tissue Specificity

Expressed in colon, placenta, liver and very weakly in exocervix. Increased expression observed in lymph nodes of breast carcinoma. {ECO:0000269PubMed:17213200, ECO:0000269PubMed:2422083, ECO:0000269PubMed:2434380, ECO:0000269PubMed:2434381}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 107 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	107 [view]
Protein-Protein	107 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005198	structural molecule activity
GO:0005515	protein binding
GO:0044822	poly(A) RNA binding
GO:0097110	scaffold protein binding

Biological Process

GO:0007049	cell cycle
GO:0009653	anatomical structure morphogenesis
GO:0016032	viral process
GO:0033209	tumor necrosis factor-mediated signaling pathway
GO:0043000	Golgi to plasma membrane CFTR protein transport
GO:0043066	negative regulation of apoptotic process
GO:0045104	intermediate filament cytoskeleton organization
GO:0097191	extrinsic apoptotic signaling pathway
GO:0097284	hepatocyte apoptotic process

Cellular Component

GO:0005730	nucleolus
GO:0005737	cytoplasm
GO:0005815	microtubule organizing center
GO:0005882	intermediate filament
GO:0034451	centriolar satellite
GO:0045095	keratin filament
GO:0048471	perinuclear region of cytoplasm
GO:0070062	extracellular vesicular exosome
GO:0071944	cell periphery