Version 5.4
Homo sapiens Gene: KRT18
Summary
InnateDB Gene IDBG-35299.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol KRT18
Gene Name keratin 18
Synonyms CYK18; K18
Species Homo sapiens
Ensembl Gene ENSG00000111057
Encoded Proteins
IDBP-35303
keratin 18
IDBP-35305
keratin 18
IDBP-583331
keratin 18
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary KRT18 encodes the type I intermediate filament chain keratin 18. Keratin 18, together with its filament partner keratin 8, are perhaps the most commonly found members of the intermediate filament gene family. They are expressed in single layer epithelial tissues of the body. Mutations in this gene have been linked to cryptogenic cirrhosis. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 12:52948871-52952901
Strand Forward strand
Band q13.13
Transcripts
ENST00000388835 ENSP00000373487
ENST00000388837 ENSP00000373489
ENST00000550600 ENSP00000447278
ENST00000549078
ENST00000548015
ENST00000546656
ENST00000548496
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 107 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 107 [view]
Protein-Protein 107 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005198 structural molecule activity
GO:0005515 protein binding
GO:0044822 poly(A) RNA binding
GO:0097110 scaffold protein binding
Biological Process
GO:0007049 cell cycle
GO:0009653 anatomical structure morphogenesis
GO:0016032 viral process
GO:0033209 tumor necrosis factor-mediated signaling pathway
GO:0043000 Golgi to plasma membrane CFTR protein transport
GO:0043066 negative regulation of apoptotic process
GO:0045104 intermediate filament cytoskeleton organization
GO:0097191 extrinsic apoptotic signaling pathway
GO:0097284 hepatocyte apoptotic process
Cellular Component
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0005815 microtubule organizing center
GO:0005882 intermediate filament
GO:0034451 centriolar satellite
GO:0045095 keratin filament
GO:0048471 perinuclear region of cytoplasm
GO:0070062 extracellular vesicular exosome
GO:0071944 cell periphery
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000023043
View Gene Order
ENSBTAG00000001517
Not yet available
Pathways
NETPATH
NetPath_4
EGFR1 pathway
REACTOME
KEGG
hsa05130
Pathogenic Escherichia coli infection pathway
INOH
PID NCI
caspase_pathway
Caspase Cascade in Apoptosis
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.598127
RefSeq NM_000224 NM_199187
HUGO
OMIM
CCDS CCDS31809
HPRD 01020
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca