InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: SLCO4C1

Summary

InnateDB Protein

IDBP-35382.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SLCO4C1

Protein Name

solute carrier organic anion transporter family, member 4C1

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000309741

InnateDB Gene

IDBG-35380 (SLCO4C1)

Protein Structure

UniProt Annotation

Function

Organic anion transporter, capable of transporting pharmacological substances such as digoxin, ouabain, thyroxine, methotrexate and cAMP. May participate in the regulation of membrane transport of ouabain. Involved in the uptake of the dipeptidyl peptidase-4 inhibitor sitagliptin and hence may play a role in its transport into and out of renal proximal tubule cells. May be involved in the first step of the transport pathway of digoxin and various compounds into the urine in the kidney. May be involved in sperm maturation by enabling directed movement of organic anions and compounds within or between cells. This ion- transporting process is important to maintain the strict epididymal homeostasis necessary for sperm maturation. May have a role in secretory functions since seminal vesicle epithelial cells are assumed to secrete proteins involved in decapacitation by modifying surface proteins to facilitate the acquisition of the ability to fertilize the egg. {ECO:0000250UniProtKB:Q8BGD4, ECO:0000269PubMed:14993604, ECO:0000269PubMed:17314201}.

Subcellular Localization

Basolateral cell membrane {ECO:0000250UniProtKB:Q71MB6}; Multi-pass membrane protein {ECO:0000250UniProtKB:Q71MB6}. Note=Detected at the basolateral membrane of the proximal tubule cell in the kidney. {ECO:0000250UniProtKB:Q71MB6}.

Disease Associations

Tissue Specificity

Predominantly expressed in kidney but also weakly expressed in both fetal liver and kidney. {ECO:0000269PubMed:14993604}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005215	transporter activity
GO:0005515	protein binding

Biological Process

GO:0006810	transport
GO:0007275	multicellular organismal development
GO:0007283	spermatogenesis
GO:0030154	cell differentiation
GO:0043252	sodium-independent organic anion transport
GO:0055085	transmembrane transport

Cellular Component

GO:0005886	plasma membrane
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0016323	basolateral plasma membrane
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

InterPro

IPR002350 Kazal domain
IPR004156 Organic anion transporter polypeptide OATP
IPR011701 Major facilitator superfamily
IPR016196 Major facilitator superfamily domain, general substrate transporter
IPR020846 Major facilitator superfamily domain

PFAM

PF00050
PF07648
PF03137
PF07690

PRINTS

PIRSF

SMART

SM00280

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q6ZQN7