InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: DYNC1LI2

Summary

InnateDB Protein

IDBP-35490.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

DYNC1LI2

Protein Name

dynein, cytoplasmic 1, light intermediate chain 2

Synonyms

DNCLI2; LIC2;

Species

Homo sapiens

Ensembl Protein

ENSP00000258198

InnateDB Gene

IDBG-35488 (DYNC1LI2)

Protein Structure

UniProt Annotation

Function

Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in binding dynein to membranous organelles or chromosomes.

Subcellular Localization

Cytoplasm, cytoskeleton {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 30 experimentally validated interaction(s) in this database.

Experimentally validated
Total	30 [view]
Protein-Protein	30 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003777	microtubule motor activity
GO:0005515	protein binding
GO:0005524	ATP binding

Biological Process

GO:0000226	microtubule cytoskeleton organization
GO:0006810	transport
GO:0007018	microtubule-based movement
GO:0008152	metabolic process
GO:0019886	antigen processing and presentation of exogenous peptide antigen via MHC class II
GO:0051642	centrosome localization