InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: EIF4B

Summary

InnateDB Protein

IDBP-35512.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

EIF4B

Protein Name

eukaryotic translation initiation factor 4B

Synonyms

EIF-4B; PRO1843;

Species

Homo sapiens

Ensembl Protein

ENSP00000262056

InnateDB Gene

IDBG-35510 (EIF4B)

Protein Structure

UniProt Annotation

Function

Required for the binding of mRNA to ribosomes. Functions in close association with EIF4-F and EIF4-A. Binds near the 5'- terminal cap of mRNA in presence of EIF-4F and ATP. Promotes the ATPase activity and the ATP-dependent RNA unwinding activity of both EIF4-A and EIF4-F.

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 70 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	70 [view]
Protein-Protein	69 [view]
Protein-DNA	0
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0003676	nucleic acid binding
GO:0003723	RNA binding
GO:0003743	translation initiation factor activity
GO:0005515	protein binding
GO:0044822	poly(A) RNA binding

Biological Process

GO:0000288	nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
GO:0000289	nuclear-transcribed mRNA poly(A) tail shortening
GO:0006412	translation
GO:0006413	translational initiation
GO:0006446	regulation of translational initiation
GO:0008286	insulin receptor signaling pathway
GO:0010467	gene expression
GO:0016070	RNA metabolic process
GO:0016071	mRNA metabolic process
GO:0044267	cellular protein metabolic process