InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: EPS15L1

Summary

InnateDB Protein

IDBP-35515.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

EPS15L1

Protein Name

epidermal growth factor receptor pathway substrate 15-like 1

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000248070

InnateDB Gene

IDBG-35513 (EPS15L1)

Protein Structure

UniProt Annotation

Function

Seems to be a constitutive component of clathrin-coated pits that is required for receptor-mediated endocytosis. Involved in endocytosis of integrin beta-1 (ITGB1) and transferrin receptor (TFR); internalization of ITGB1 as DAB2-dependent cargo but not TFR seems to require association with DAB2. {ECO:0000269PubMed:22648170, ECO:0000269PubMed:9407958}.

Subcellular Localization

Cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Nucleus {ECO:0000250}. Membrane, coated pit {ECO:0000250}. Note=Localized to plasma membrane coated pits. {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 26 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	26 [view]
Protein-Protein	25 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005509	calcium ion binding
GO:0005515	protein binding

Biological Process

GO:0006897	endocytosis
GO:0007173	epidermal growth factor receptor signaling pathway
GO:0042059	negative regulation of epidermal growth factor receptor signaling pathway