InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: E2F8

Summary

InnateDB Protein

IDBP-35573.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

E2F8

Protein Name

E2F transcription factor 8

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000250024

InnateDB Gene

IDBG-35571 (E2F8)

Protein Structure

UniProt Annotation

Function

Atypical E2F transcription factor that participates in various processes such as angiogenesis and polyploidization of specialized cells. Mainly acts as a transcription repressor that binds DNA independently of DP proteins and specifically recognizes the E2 recognition site 5'-TTTC[CG]CGC-3'. Directly represses transcription of classical E2F transcription factors such as E2F1: component of a feedback loop in S phase by repressing the expression of E2F1, thereby preventing p53/TP53-dependent apoptosis. Plays a key role in polyploidization of cells in placenta and liver by regulating the endocycle, probably by repressing genes promoting cytokinesis and antagonizing action of classical E2F proteins (E2F1, E2F2 and/or E2F3). Required for placental development by promoting polyploidization of trophoblast giant cells. Acts as a promoter of sprouting angiogenesis, possibly by acting as a transcription activator: associates with HIF1A, recognizes and binds the VEGFA promoter, which is different from canonical E2 recognition site, and activates expression of the VEGFA gene. {ECO:0000269PubMed:15897886, ECO:0000269PubMed:16179649, ECO:0000269PubMed:18202719, ECO:0000269PubMed:22903062}.

Subcellular Localization

Nucleus {ECO:0000269PubMed:15897886}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.

Experimentally validated
Total	6 [view]
Protein-Protein	6 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000978	RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0001047	core promoter binding
GO:0001078	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0003714	transcription corepressor activity
GO:0005515	protein binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0001890	placenta development
GO:0002040	sprouting angiogenesis
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0032466	negative regulation of cytokinesis
GO:0032877	positive regulation of DNA endoreduplication
GO:0033301	cell cycle comprising mitosis without cytokinesis
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0060707	trophoblast giant cell differentiation
GO:0060718	chorionic trophoblast cell differentiation
GO:0070365	hepatocyte differentiation