InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: PDP2

Summary

InnateDB Protein

IDBP-35688.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PDP2

Protein Name

pyruvate dehyrogenase phosphatase catalytic subunit 2

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000309548

InnateDB Gene

IDBG-35686 (PDP2)

Protein Structure

UniProt Annotation

Function

Catalyzes the dephosphorylation and concomitant reactivation of the alpha subunit of the E1 component of the pyruvate dehydrogenase complex. {ECO:0000250}.

Subcellular Localization

Mitochondrion matrix {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003824	catalytic activity
GO:0004722	protein serine/threonine phosphatase activity
GO:0004724	magnesium-dependent protein serine/threonine phosphatase activity
GO:0004741	[pyruvate dehydrogenase (lipoamide)] phosphatase activity
GO:0046872	metal ion binding

Biological Process

GO:0006090	pyruvate metabolic process
GO:0006470	protein dephosphorylation
GO:0010510	regulation of acetyl-CoA biosynthetic process from pyruvate
GO:0035970	peptidyl-threonine dephosphorylation
GO:0044237	cellular metabolic process
GO:0044281	small molecule metabolic process