InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: PDE5A

Summary

InnateDB Protein

IDBP-35775.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PDE5A

Protein Name

phosphodiesterase 5A, cGMP-specific

Synonyms

CGB-PDE; CN5A; PDE5;

Species

Homo sapiens

Ensembl Protein

ENSP00000347046

InnateDB Gene

IDBG-35773 (PDE5A)

Protein Structure

UniProt Annotation

Function

Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. This phosphodiesterase catalyzes the specific hydrolysis of cGMP to 5'- GMP.

Subcellular Localization

Disease Associations

Tissue Specificity

Expressed in aortic smooth muscle cells, heart, placenta, skeletal muscle and pancreas and, to a much lesser extent, in brain, liver and lung.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.

Experimentally validated
Total	4 [view]
Protein-Protein	4 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004112	cyclic-nucleotide phosphodiesterase activity
GO:0004114	3',5'-cyclic-nucleotide phosphodiesterase activity
GO:0005515	protein binding
GO:0030553	cGMP binding
GO:0046872	metal ion binding
GO:0047555	3',5'-cyclic-GMP phosphodiesterase activity

Biological Process

GO:0007165	signal transduction
GO:0007596	blood coagulation
GO:0010613	positive regulation of cardiac muscle hypertrophy
GO:0042130	negative regulation of T cell proliferation
GO:0043406	positive regulation of MAP kinase activity
GO:0046068	cGMP metabolic process
GO:0046069	cGMP catabolic process
GO:0055118	negative regulation of cardiac muscle contraction
GO:0055119	relaxation of cardiac muscle
GO:0060282	positive regulation of oocyte development

Cellular Component

GO:0005575	cellular_component
GO:0005829	cytosol

Protein Structure and Domains

PDB ID

InterPro

IPR002073 3\'5\'-cyclic nucleotide phosphodiesterase, catalytic domain
IPR003018 GAF domain
IPR003607 HD/PDEase domain
IPR023088 3\'5\'-cyclic nucleotide phosphodiesterase
IPR029016 GAF domain-like

PFAM

PF00233
PF01590
PF13185
PF13492

PRINTS

PR00387

PIRSF

SMART

SM00065
SM00471

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt