InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: PDE5A

Summary

InnateDB Gene

IDBG-35773.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PDE5A

Gene Name

phosphodiesterase 5A, cGMP-specific

Synonyms

CGB-PDE; CN5A; PDE5

Species

Homo sapiens

Ensembl Gene

ENSG00000138735

Encoded Proteins

IDBP-35775

phosphodiesterase 5A, cGMP-specific

IDBP-35779

phosphodiesterase 5A, cGMP-specific

IDBP-241556

phosphodiesterase 5A, cGMP-specific

IDBP-376753

phosphodiesterase 5A, cGMP-specific

IDBP-483075

phosphodiesterase 5A, cGMP-specific

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes a cGMP-binding, cGMP-specific phosphodiesterase, a member of the cyclic nucleotide phosphodiesterase family. This phosphodiesterase specifically hydrolyzes cGMP to 5'-GMP. It is involved in the regulation of intracellular concentrations of cyclic nucleotides and is important for smooth muscle relaxation in the cardiovascular system. Alternative splicing of this gene results in three transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2008]
This gene encodes a cGMP-binding, cGMP-specific phosphodiesterase, a member of the cyclic nucleotide phosphodiesterase family. This phosphodiesterase specifically hydrolyzes cGMP to 5\'-GMP. It is involved in the regulation of intracellular concentrations of cyclic nucleotides and is important for smooth muscle relaxation in the cardiovascular system. Alternative splicing of this gene results in three transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 4:119494395-119628991

Strand

Reverse strand

Band

q26

Transcripts

ENST00000354960	ENSP00000347046
ENST00000264805	ENSP00000264805
ENST00000394439	ENSP00000377957
ENST00000420633	ENSP00000416309
ENST00000503412	ENSP00000425810
ENST00000512494
ENST00000509612
ENST00000513594
ENST00000512450
ENST00000512739
ENST00000502912
ENST00000508914

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.

Experimentally validated
Total	4 [view]
Protein-Protein	4 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004112	cyclic-nucleotide phosphodiesterase activity
GO:0004114	3',5'-cyclic-nucleotide phosphodiesterase activity
GO:0005515	protein binding
GO:0030553	cGMP binding
GO:0046872	metal ion binding
GO:0047555	3',5'-cyclic-GMP phosphodiesterase activity

Biological Process

GO:0007165	signal transduction
GO:0007596	blood coagulation
GO:0010613	positive regulation of cardiac muscle hypertrophy
GO:0042130	negative regulation of T cell proliferation
GO:0043406	positive regulation of MAP kinase activity
GO:0046068	cGMP metabolic process
GO:0046069	cGMP catabolic process
GO:0055118	negative regulation of cardiac muscle contraction
GO:0055119	relaxation of cardiac muscle
GO:0060282	positive regulation of oocyte development

Cellular Component

GO:0005575	cellular_component
GO:0005829	cytosol

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000053965

View Gene Order

ENSBTAG00000024888

Not yet available

Pathways

NETPATH

REACTOME

REACT_23767

cGMP effects pathway

REACT_23862

Nitric oxide stimulates guanylate cyclase pathway

REACT_23876

Platelet homeostasis pathway

REACT_604

Hemostasis pathway

KEGG

hsa00230

Purine metabolism pathway

INOH

INOH website

Purine nucleotides nucleosides metabolism pathway

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Hs.647971 Hs.690665

RefSeq

NM_001083 NM_033430 NM_033437

HUGO

OMIM

CCDS

CCDS34055 CCDS3713

HPRD

04497

IMGT

EMBL

GenPept

RNA Seq Atlas