InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ADCY8

Summary

InnateDB Protein

IDBP-35782.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ADCY8

Protein Name

adenylate cyclase 8 (brain)

Synonyms

AC8; ADCY3; HBAC1;

Species

Homo sapiens

Ensembl Protein

ENSP00000286355

InnateDB Gene

IDBG-35780 (ADCY8)

Protein Structure

UniProt Annotation

Function

This is a membrane-bound, calcium-stimulable adenylyl cyclase. May be involved in learning, in memory and in drug dependence (By similarity). {ECO:0000250}.

Subcellular Localization

Membrane; Multi-pass membrane protein.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0004016	adenylate cyclase activity
GO:0005524	ATP binding
GO:0008294	calcium- and calmodulin-responsive adenylate cyclase activity
GO:0016849	phosphorus-oxygen lyase activity
GO:0046872	metal ion binding

Biological Process

GO:0006112	energy reserve metabolic process
GO:0006171	cAMP biosynthetic process
GO:0006833	water transport
GO:0007165	signal transduction
GO:0007173	epidermal growth factor receptor signaling pathway
GO:0007189	adenylate cyclase-activating G-protein coupled receptor signaling pathway
GO:0007193	adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway
GO:0007202	activation of phospholipase C activity
GO:0007268	synaptic transmission
GO:0007611	learning or memory
GO:0007616	long-term memory
GO:0008543	fibroblast growth factor receptor signaling pathway
GO:0009190	cyclic nucleotide biosynthetic process
GO:0034199	activation of protein kinase A activity
GO:0035556	intracellular signal transduction
GO:0044281	small molecule metabolic process
GO:0045087	innate immune response (InnateDB)
GO:0048011	neurotrophin TRK receptor signaling pathway
GO:0055085	transmembrane transport
GO:0071377	cellular response to glucagon stimulus