Version 5.4
Homo sapiens Gene: ADCY8
Summary
InnateDB Gene IDBG-35780.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ADCY8
Gene Name adenylate cyclase 8 (brain)
Synonyms AC8; ADCY3; HBAC1
Species Homo sapiens
Ensembl Gene ENSG00000155897
Encoded Proteins
IDBP-35782
adenylate cyclase 8 (brain)
IDBP-35784
adenylate cyclase 8 (brain)
IDBP-483639
adenylate cyclase 8 (brain)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 25368329
SCN5A is a novel pathogen sensor that initiates anti-viral signalling and transcription through ADCY8 and ATF2.
Entrez Gene
Summary Adenylate cyclase is a membrane bound enzyme that catalyses the formation of cyclic AMP from ATP. The enzymatic activity is under the control of several hormones, and different polypeptides participate in the transduction of the signal from the receptor to the catalytic moiety. Stimulatory or inhibitory receptors (Rs and Ri) interact with G proteins (Gs and Gi) that exhibit GTPase activity and they modulate the activity of the catalytic subunit of the adenylyl cyclase [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 8:130780301-131042426
Strand Reverse strand
Band q24.22
Transcripts
ENST00000286355 ENSP00000286355
ENST00000377928 ENSP00000367161
ENST00000522949 ENSP00000428010
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated
Total 3 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000166 nucleotide binding
GO:0004016 adenylate cyclase activity
GO:0005524 ATP binding
GO:0008294 calcium- and calmodulin-responsive adenylate cyclase activity
GO:0016849 phosphorus-oxygen lyase activity
GO:0046872 metal ion binding
Biological Process
GO:0006112 energy reserve metabolic process
GO:0006171 cAMP biosynthetic process
GO:0006833 water transport
GO:0007165 signal transduction
GO:0007173 epidermal growth factor receptor signaling pathway
GO:0007189 adenylate cyclase-activating G-protein coupled receptor signaling pathway
GO:0007193 adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway
GO:0007202 activation of phospholipase C activity
GO:0007268 synaptic transmission
GO:0007611 learning or memory
GO:0007616 long-term memory
GO:0008543 fibroblast growth factor receptor signaling pathway
GO:0009190 cyclic nucleotide biosynthetic process
GO:0034199 activation of protein kinase A activity
GO:0035556 intracellular signal transduction
GO:0044281 small molecule metabolic process
GO:0045087 innate immune response (InnateDB)
GO:0048011 neurotrophin TRK receptor signaling pathway
GO:0055085 transmembrane transport
GO:0071377 cellular response to glucagon stimulus
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000022376
View Gene Order
ENSBTAG00000014600
Not yet available
Pathways
NETPATH
REACTOME
REACT_15530
PKA activation pathway
REACT_15497
PKA-mediated phosphorylation of CREB pathway
REACT_9000
Calmodulin induced events pathway
REACT_9053
CaM pathway pathway
REACT_111064
DAG and IP3 signaling pathway
REACT_147814
DAP12 signaling pathway
REACT_147694
DAP12 interactions pathway
REACT_24023
Vasopressin regulates renal water homeostasis via Aquaporins pathway
REACT_12079
PLC-gamma1 signalling pathway
REACT_12478
EGFR interacts with phospholipase C-gamma pathway
REACT_9417
Signaling by EGFR pathway
REACT_19231
G alpha (i) signalling events pathway
REACT_19327
G alpha (s) signalling events pathway
REACT_19333
G alpha (z) signalling events pathway
REACT_15312
Adenylate cyclase activating pathway pathway
REACT_15333
Adenylate cyclase inhibitory pathway pathway
REACT_15426
PLC beta mediated events pathway
REACT_15295
Opioid Signalling pathway
REACT_115720
PLCG1 events in ERBB2 signaling pathway
REACT_115755
Signaling by ERBB2 pathway
REACT_21310
Phospholipase C-mediated cascade pathway
REACT_9470
Signaling by FGFR pathway
REACT_17025
Downstream signal transduction pathway
REACT_16888
Signaling by PDGF pathway
REACT_25031
GABA B receptor activation pathway
REACT_18274
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion pathway
REACT_18325
Regulation of insulin secretion pathway
REACT_1946
PKA activation in glucagon signalling pathway
REACT_1665
Glucagon signaling in metabolic regulation pathway
REACT_1505
Integration of energy metabolism pathway
REACT_20625
CREB phosphorylation through the activation of Adenylate Cyclase pathway
REACT_120736
Signaling by FGFR in disease pathway
REACT_15518
Transmembrane transport of small molecules pathway
REACT_11061
Signalling by NGF pathway
REACT_228134
Signaling by Hedgehog pathway
REACT_115871
Signaling by EGFR in Cancer pathway
REACT_21272
Downstream signaling of activated FGFR pathway
REACT_13685
Neuronal System pathway
REACT_14797
Signaling by GPCR pathway
REACT_6802
Innate Immune System pathway
REACT_25199
GABA receptor activation pathway
REACT_25330
Activation of GABAB receptors pathway
REACT_111102
Signal Transduction pathway
REACT_19184
GPCR downstream signaling pathway
REACT_267634
Hedgehog 'off' state pathway
REACT_20593
Post NMDA receptor activation events pathway
REACT_15526
G-protein mediated events pathway
REACT_6900
Immune System pathway
REACT_20563
Activation of NMDA receptor upon glutamate binding and postsynaptic events pathway
REACT_12056
NGF signalling via TRKA from the plasma membrane pathway
REACT_13477
Transmission across Chemical Synapses pathway
REACT_15370
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell pathway
REACT_111217
Metabolism pathway
REACT_25282
Inhibition of adenylate cyclase pathway pathway
REACT_15307
Ca-dependent events pathway
REACT_23887
Aquaporin-mediated transport pathway
REACT_116125
Disease pathway
KEGG
hsa04912
GnRH signaling pathway pathway
hsa04540
Gap junction pathway
hsa00230
Purine metabolism pathway
hsa04720
Long-term potentiation pathway
hsa04742
Taste transduction pathway
hsa04020
Calcium signaling pathway pathway
hsa04916
Melanogenesis pathway
hsa04270
Vascular smooth muscle contraction pathway
hsa04062
Chemokine signaling pathway pathway
hsa04914
Progesterone-mediated oocyte maturation pathway
hsa05414
Dilated cardiomyopathy pathway
hsa04114
Oocyte meiosis pathway
hsa04971
Gastric acid secretion pathway
hsa04972
Pancreatic secretion pathway
hsa04970
Salivary secretion pathway
hsa04976
Bile secretion pathway
INOH
INOH website
GPCR Adenosine A2A receptor signaling pathway pathway
INOH website
Purine nucleotides nucleosides metabolism pathway
INOH website
GPCR signaling pathway
PID NCI
Cross-References
SwissProt
TrEMBL E5RFR2
UniProt Splice Variant
Entrez Gene 114
UniGene Hs.591859
RefSeq NM_001115
HUGO HGNC:239
OMIM 103070
CCDS CCDS6363
HPRD 00051
IMGT
EMBL AC011974 AC037453 AC087341 AC103726
GenPept
RNA Seq Atlas 114

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca