InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: IGFBP6

Summary

InnateDB Protein

IDBP-35798.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

IGFBP6

Protein Name

insulin-like growth factor binding protein 6

Synonyms

IBP6;

Species

Homo sapiens

Ensembl Protein

ENSP00000301464

InnateDB Gene

IDBG-35796 (IGFBP6)

Protein Structure

UniProt Annotation

Function

IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors.

Subcellular Localization

Secreted.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.

Experimentally validated
Total	5 [view]
Protein-Protein	3 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005520	insulin-like growth factor binding
GO:0031994	insulin-like growth factor I binding

Biological Process

GO:0001558	regulation of cell growth
GO:0007165	signal transduction
GO:0008285	negative regulation of cell proliferation
GO:0044267	cellular protein metabolic process

Cellular Component

GO:0005576	extracellular region
GO:0005615	extracellular space
GO:0005737	cytoplasm
GO:0005794	Golgi apparatus
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

InterPro

IPR000716 Thyroglobulin type-1
IPR000867 Insulin-like growth factor-binding protein, IGFBP
IPR009030 Insulin-like growth factor binding protein, N-terminal
IPR022321 Insulin-like growth factor-binding protein family 1-6, chordata
IPR022326 Insulin-like growth factor-binding protein 6

PFAM

PF00086
PF00219

PRINTS

PR01976
PR01982

PIRSF

SMART

SM00211
SM00121

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt