InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: RBM5

Summary

InnateDB Protein

IDBP-35858.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

RBM5

Protein Name

RNA binding motif protein 5

Synonyms

G15; LUCA15; RMB5;

Species

Homo sapiens

Ensembl Protein

ENSP00000343054

InnateDB Gene

IDBG-35856 (RBM5)

Protein Structure

UniProt Annotation

Function

Component of the spliceosome A complex. Regulates alternative splicing of a number of mRNAs. May modulate splice site pairing after recruitment of the U1 and U2 snRNPs to the 5' and 3' splice sites of the intron. May both positively and negatively regulate aopotosis by regulating the alternative splicing of several genes involved in this process, including FAS and CASP2/caspase-2. In the case of FAS, promotes exclusion of exon 6 thereby producing a soluble form of FAS that inhibits apoptosis. In the case of CASP2/caspase-2, promotes exclusion of exon 9 thereby producing a catalytically active form of CASP2/Caspase-2 that induces apoptosis. {ECO:0000269PubMed:10949932, ECO:0000269PubMed:12207175, ECO:0000269PubMed:12581154, ECO:0000269PubMed:15192330, ECO:0000269PubMed:16585163, ECO:0000269PubMed:18840686, ECO:0000269PubMed:18851835}.

Subcellular Localization

Nucleus {ECO:0000269PubMed:18851835}.

Disease Associations

Tissue Specificity

Isoform 5 is widely expressed in normal tissues and is expressed at increased levels in T-leukemic cell lines.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 35 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	35 [view]
Protein-Protein	35 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0003676	nucleic acid binding
GO:0003677	DNA binding
GO:0003723	RNA binding
GO:0003729	mRNA binding
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0044822	poly(A) RNA binding
GO:0046872	metal ion binding

Biological Process

GO:0000245	spliceosomal complex assembly
GO:0000381	regulation of alternative mRNA splicing, via spliceosome
GO:0000398	mRNA splicing, via spliceosome
GO:0006396	RNA processing
GO:0006915	apoptotic process
GO:0008285	negative regulation of cell proliferation
GO:0008380	RNA splicing
GO:0010467	gene expression
GO:0043065	positive regulation of apoptotic process