InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: RBM5

Summary

InnateDB Gene

IDBG-35856.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

RBM5

Gene Name

RNA binding motif protein 5

Synonyms

G15; LUCA15; RMB5

Species

Homo sapiens

Ensembl Gene

ENSG00000003756

Encoded Proteins

IDBP-35858

RNA binding motif protein 5

IDBP-240059

RNA binding motif protein 5

IDBP-294235

RNA binding motif protein 5

IDBP-377904

RNA binding motif protein 5

IDBP-377905

RNA binding motif protein 5

IDBP-377906

RNA binding motif protein 5

IDBP-377908

RNA binding motif protein 5

IDBP-479843

RNA binding motif protein 5

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene is a candidate tumor suppressor gene which encodes a nuclear RNA binding protein that is a component of the spliceosome A complex. The encoded protein plays a role in the induction of cell cycle arrest and apoptosis through pre-mRNA splicing of multiple target genes including the tumor suppressor protein p53. This gene is located within the tumor suppressor region 3p21.3, and may play a role in the inhibition of tumor transformation and progression of several malignancies including lung cancer. [provided by RefSeq, Oct 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 3:50088908-50119021

Strand

Forward strand

Band

p21.31

Transcripts

ENST00000347869	ENSP00000343054
ENST00000395174	ENSP00000378603
ENST00000404526	ENSP00000384872
ENST00000433556
ENST00000441305	ENSP00000390711
ENST00000438369	ENSP00000414218
ENST00000437500	ENSP00000394622
ENST00000417905	ENSP00000406119
ENST00000441812
ENST00000469838	ENSP00000419534
ENST00000464087
ENST00000492472
ENST00000496179
ENST00000462025
ENST00000471995
ENST00000474818
ENST00000494360
ENST00000489437
ENST00000474470
ENST00000475128
ENST00000493993
ENST00000475590
ENST00000492430
ENST00000479275
ENST00000464988
ENST00000461242

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 35 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	35 [view]
Protein-Protein	35 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0003676	nucleic acid binding
GO:0003677	DNA binding
GO:0003723	RNA binding
GO:0003729	mRNA binding
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0044822	poly(A) RNA binding
GO:0046872	metal ion binding

Biological Process

GO:0000245	spliceosomal complex assembly
GO:0000381	regulation of alternative mRNA splicing, via spliceosome
GO:0000398	mRNA splicing, via spliceosome
GO:0006396	RNA processing
GO:0006915	apoptotic process
GO:0008285	negative regulation of cell proliferation
GO:0008380	RNA splicing
GO:0010467	gene expression
GO:0043065	positive regulation of apoptotic process

Cellular Component

GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005681	spliceosomal complex

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000032580

View Gene Order

ENSBTAG00000006330

Not yet available

Pathways

NETPATH

REACTOME

REACT_467

mRNA Splicing - Major Pathway pathway

REACT_125

Processing of Capped Intron-Containing Pre-mRNA pathway

REACT_1735

mRNA Splicing pathway

REACT_71

Gene Expression pathway

KEGG

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Hs.439480 Hs.609825 Hs.639235 Hs.735496

RefSeq

NM_005778

HUGO

OMIM

CCDS

CCDS2810

HPRD

06052

IMGT

EMBL

GenPept

RNA Seq Atlas