InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: MAD2L1

Summary

InnateDB Protein

IDBP-35921.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

MAD2L1

Protein Name

MAD2 mitotic arrest deficient-like 1 (yeast)

Synonyms

HSMAD2; MAD2;

Species

Homo sapiens

Ensembl Protein

ENSP00000296509

InnateDB Gene

IDBG-35919 (MAD2L1)

Protein Structure

UniProt Annotation

Function

Component of the spindle-assembly checkpoint that prevents the onset of anaphase until all chromosomes are properly aligned at the metaphase plate. Required for the execution of the mitotic checkpoint which monitors the process of kinetochore- spindle attachment and inhibits the activity of the anaphase promoting complex by sequestering CDC20 until all chromosomes are aligned at the metaphase plate. {ECO:0000269PubMed:10700282, ECO:0000269PubMed:11804586, ECO:0000269PubMed:15024386}.

Subcellular Localization

Nucleus. Chromosome, centromere, kinetochore. Cytoplasm. Cytoplasm, cytoskeleton, spindle pole. Note=Recruited by MAD1L1 to unattached kinetochores (Probable). Recruited to the nuclear pore complex by TPR during interphase. Recruited to kinetochores in late prometaphase after BUB1, CENPF, BUB1B and CENPE. Kinetochore association requires the presence of NEK2. Kinetochore association is repressed by UBD. {ECO:0000305}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 99 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	99 [view]
Protein-Protein	93 [view]
Protein-DNA	6 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0042802	identical protein binding
GO:0042803	protein homodimerization activity

Biological Process

GO:0000070	mitotic sister chromatid segregation
GO:0000278	mitotic cell cycle
GO:0007093	mitotic cell cycle checkpoint
GO:0007094	mitotic spindle assembly checkpoint
GO:0031145	anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process
GO:0042177	negative regulation of protein catabolic process
GO:0043066	negative regulation of apoptotic process
GO:0045930	negative regulation of mitotic cell cycle
GO:0051436	negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
GO:0051439	regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
GO:0060564	negative regulation of mitotic anaphase-promoting complex activity
GO:0090267	positive regulation of mitotic cell cycle spindle assembly checkpoint

Cellular Component

GO:0000775	chromosome, centromeric region
GO:0000776	kinetochore
GO:0000777	condensed chromosome kinetochore
GO:0000922	spindle pole
GO:0005634	nucleus
GO:0005643	nuclear pore
GO:0005829	cytosol
GO:0048471	perinuclear region of cytoplasm
GO:0072686	mitotic spindle