InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: PRDM5

Summary

InnateDB Protein

IDBP-35976.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PRDM5

Protein Name

PR domain containing 5

Synonyms

BCS2; PFM2;

Species

Homo sapiens

Ensembl Protein

ENSP00000264808

InnateDB Gene

IDBG-35974 (PRDM5)

Protein Structure

UniProt Annotation

Function

Sequence-specific DNA-binding transcription factor. Represses transcription at least in part by recruitment of the histone methyltransferase EHMT2/G9A and histone deacetylases such as HDAC1. Regulates hematopoiesis-associated protein-coding and microRNA (miRNA) genes. May regulate the expression of proteins involved in extracellular matrix development and maintenance, including fibrillar collagens, such as COL4A1 and COL11A1, connective tissue components, such as HAPLN1, and molecules regulating cell migration and adhesion, including EDIL3 and TGFB2. May caused G2/M arrest and apoptosis in cancer cells. {ECO:0000269PubMed:15077163, ECO:0000269PubMed:17636019, ECO:0000269PubMed:21664999}.

Subcellular Localization

Nucleus {ECO:0000269PubMed:15077163, ECO:0000269PubMed:17636019}.

Disease Associations

Brittle cornea syndrome 2 (BCS2) [MIM:614170]: A disorder characterized by extreme corneal thinning resulting in corneal rupture after minor trauma, blue sclerae, keratoconus or keratoglobus, hyperelasticity of the skin, and hypermobile joints. {ECO:0000269PubMed:21664999}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Tissue Specificity

Widely expressed with highest levels in colon and ovary. Tends to be silenced in breast, colorectal, gastric and liver cancer tissues. {ECO:0000269PubMed:15077163, ECO:0000269PubMed:17699856}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	4 [view]
Protein-Protein	3 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000976	transcription regulatory region sequence-specific DNA binding
GO:0005515	protein binding
GO:0008168	methyltransferase activity
GO:0043565	sequence-specific DNA binding
GO:0044212	transcription regulatory region DNA binding
GO:0046872	metal ion binding
GO:0070491	repressing transcription factor binding

Biological Process

GO:0000278	mitotic cell cycle
GO:0006351	transcription, DNA-templated
GO:0016575	histone deacetylation
GO:0045892	negative regulation of transcription, DNA-templated
GO:0051567	histone H3-K9 methylation

Cellular Component

GO:0005634

nucleus

Protein Structure and Domains

PDB ID

InterPro

IPR001214 SET domain
IPR007087 Zinc finger, C2H2
IPR015880 Zinc finger, C2H2-like
IPR017125 PR-domain zinc finger protein PRDM5
IPR022755 Zinc finger, double-stranded RNA binding

PFAM

PF00856
PF00096
PF12171

PRINTS

PIRSF

PIRSF037162

SMART

SM00317
SM00355

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt