InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: TRADD

Summary

InnateDB Protein

IDBP-36012.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TRADD

Protein Name

TNFRSF1A-associated via death domain

Synonyms

Hs.89862;

Species

Homo sapiens

Ensembl Protein

ENSP00000341268

InnateDB Gene

IDBG-36010 (TRADD)

Protein Structure

UniProt Annotation

Function

The nuclear form acts as a tumor suppressor by preventing ubiquitination and degradation of isoform p19ARF/ARF of CDKN2A by TRIP12: acts by interacting with TRIP12, leading to disrupt interaction between TRIP12 and isoform p19ARF/ARF of CDKN2A (By similarity). Adapter molecule for TNFRSF1A/TNFR1 that specifically associates with the cytoplasmic domain of activated TNFRSF1A/TNFR1 mediating its interaction with FADD. Overexpression of TRADD leads to two major TNF-induced responses, apoptosis and activation of NF-kappa-B. {ECO:0000250}.

Subcellular Localization

Nucleus {ECO:0000250}. Cytoplasm {ECO:0000250}. Cytoplasm, cytoskeleton {ECO:0000269PubMed:11684708}. Note=Shuttles between the cytoplasm and the nucleus. {ECO:0000250}.

Disease Associations

Tissue Specificity

Found in all examined tissues.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 79 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.

Experimentally validated
Total	79 [view]
Protein-Protein	77 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	2 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	7 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004871	signal transducer activity
GO:0005164	tumor necrosis factor receptor binding
GO:0005515	protein binding
GO:0019900	kinase binding
GO:0032403	protein complex binding
GO:0042802	identical protein binding
GO:0060090	binding, bridging
GO:0070513	death domain binding

Biological Process

GO:0006915	apoptotic process
GO:0006919	activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0007165	signal transduction
GO:0008625	extrinsic apoptotic signaling pathway via death domain receptors
GO:0033209	tumor necrosis factor-mediated signaling pathway
GO:0043065	positive regulation of apoptotic process
GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0045087	innate immune response (InnateDB)
GO:0051092	positive regulation of NF-kappaB transcription factor activity
GO:0051291	protein heterooligomerization
GO:0051798	positive regulation of hair follicle development
GO:0097190	apoptotic signaling pathway
GO:0097191	extrinsic apoptotic signaling pathway
GO:2001239	regulation of extrinsic apoptotic signaling pathway in absence of ligand

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0005856	cytoskeleton
GO:0031264	death-inducing signaling complex
GO:0043234	protein complex
GO:0043235	receptor complex
GO:0045121	membrane raft