InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: TRADD

Summary

InnateDB Gene

IDBG-36010.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TRADD

Gene Name

TNFRSF1A-associated via death domain

Synonyms

Hs.89862

Species

Homo sapiens

Ensembl Gene

ENSG00000102871

Encoded Proteins

IDBP-36012

TNFRSF1A-associated via death domain

IDBP-749338

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation

Summary

PMID 18439848

TRADD is recruited to MAVS and orchestrated complex formation with TRAF3 and TANK and with FADD and RIPK1, leading to the activation of IRF3 and NF-kappaB-TRADD is not only essential in TNFR1 signalling but also in RIG-I antiviral pathway.

Entrez Gene

Summary

The protein encoded by this gene is a death domain containing adaptor molecule that interacts with TNFRSF1A/TNFR1 and mediates programmed cell death signaling and NF-kappaB activation. This protein binds adaptor protein TRAF2, reduces the recruitment of inhibitor-of-apoptosis proteins (IAPs) by TRAF2, and thus suppresses TRAF2 mediated apoptosis. This protein can also interact with receptor TNFRSF6/FAS and adaptor protein FADD/MORT1, and is involved in the Fas-induced cell death pathway. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 16:67154180-67160298

Strand

Reverse strand

Band

q22.1

Transcripts

ENST00000345057	ENSP00000341268
ENST00000486556	ENSP00000462591
ENST00000566104
ENST00000563348
ENST00000566247

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 79 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.

Experimentally validated
Total	79 [view]
Protein-Protein	77 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	2 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	7 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004871	signal transducer activity
GO:0005164	tumor necrosis factor receptor binding
GO:0005515	protein binding
GO:0019900	kinase binding
GO:0032403	protein complex binding
GO:0042802	identical protein binding
GO:0060090	binding, bridging
GO:0070513	death domain binding

Biological Process

GO:0006915	apoptotic process
GO:0006919	activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0007165	signal transduction
GO:0008625	extrinsic apoptotic signaling pathway via death domain receptors
GO:0033209	tumor necrosis factor-mediated signaling pathway
GO:0043065	positive regulation of apoptotic process
GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0045087	innate immune response (InnateDB)
GO:0051092	positive regulation of NF-kappaB transcription factor activity
GO:0051291	protein heterooligomerization
GO:0051798	positive regulation of hair follicle development
GO:0097190	apoptotic signaling pathway
GO:0097191	extrinsic apoptotic signaling pathway
GO:2001239	regulation of extrinsic apoptotic signaling pathway in absence of ligand

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0005856	cytoskeleton
GO:0031264	death-inducing signaling complex
GO:0043234	protein complex
GO:0043235	receptor complex
GO:0045121	membrane raft