InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CENPA

Summary

InnateDB Protein

IDBP-36024.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CENPA

Protein Name

centromere protein A

Synonyms

CenH3; CENP-A;

Species

Homo sapiens

Ensembl Protein

ENSP00000233505

InnateDB Gene

IDBG-36018 (CENPA)

Protein Structure

UniProt Annotation

Function

Histone H3-like variant which exclusively replaces conventional H3 in the nucleosome core of centromeric chromatin at the inner plate of the kinetochore. Required for recruitment and assembly of kinetochore proteins, mitotic progression and chromosome segregation. May serve as an epigenetic mark that propagates centromere identity through replication and cell division. The CENPA-H4 heterotetramer can bind DNA by itself (in vitro). {ECO:0000269PubMed:20739937, ECO:0000269PubMed:21478274}.

Subcellular Localization

Nucleus. Chromosome, centromere, kinetochore. Note=Localizes exclusively in the kinetochore domain of centromeres. Occupies a compact domain at the inner kinetochore plate stretching across 2 thirds of the length of the constriction but encompassing only one third of the constriction width and height.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 90 experimentally validated interaction(s) in this database.

Experimentally validated
Total	90 [view]
Protein-Protein	86 [view]
Protein-DNA	3 [view]
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003682	chromatin binding
GO:0005515	protein binding
GO:0046982	protein heterodimerization activity

Biological Process

GO:0000132	establishment of mitotic spindle orientation
GO:0000278	mitotic cell cycle
GO:0006334	nucleosome assembly
GO:0016032	viral process
GO:0034080	centromere-specific nucleosome assembly
GO:0051382	kinetochore assembly
GO:0071459	protein localization to chromosome, centromeric region

Cellular Component

GO:0000775	chromosome, centromeric region
GO:0000778	condensed nuclear chromosome kinetochore
GO:0000780	condensed nuclear chromosome, centromeric region
GO:0000786	nucleosome
GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005829	cytosol