InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: CENPA

Summary

InnateDB Gene

IDBG-36018.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CENPA

Gene Name

centromere protein A

Synonyms

CenH3; CENP-A

Species

Homo sapiens

Ensembl Gene

ENSG00000115163

Encoded Proteins

IDBP-36024

centromere protein A

IDBP-36026

centromere protein A

IDBP-368273

centromere protein A

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

Centromeres are the differentiated chromosomal domains that specify the mitotic behavior of chromosomes. CENPA encodes a centromere protein which contains a histone H3 related histone fold domain that is required for targeting to the centromere. CENPA is proposed to be a component of a modified nucleosome or nucleosome-like structure in which it replaces 1 or both copies of conventional histone H3 in the (H3-H4)2 tetrameric core of the nucleosome particle. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 2:26764289-26801067

Strand

Forward strand

Band

p23.3

Transcripts

ENST00000233505	ENSP00000233505
ENST00000335756	ENSP00000336868
ENST00000419525	ENSP00000404963
ENST00000475662
ENST00000472719
ENST00000460030

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 90 experimentally validated interaction(s) in this database.

Experimentally validated
Total	90 [view]
Protein-Protein	86 [view]
Protein-DNA	3 [view]
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003682	chromatin binding
GO:0005515	protein binding
GO:0046982	protein heterodimerization activity

Biological Process

GO:0000132	establishment of mitotic spindle orientation
GO:0000278	mitotic cell cycle
GO:0006334	nucleosome assembly
GO:0016032	viral process
GO:0034080	centromere-specific nucleosome assembly
GO:0051382	kinetochore assembly
GO:0071459	protein localization to chromosome, centromeric region

Cellular Component

GO:0000775	chromosome, centromeric region
GO:0000778	condensed nuclear chromosome kinetochore
GO:0000780	condensed nuclear chromosome, centromeric region
GO:0000786	nucleosome
GO:0000939	condensed chromosome inner kinetochore
GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005829	cytosol