Version 5.4
Homo sapiens Protein: DLGAP2
Summary
InnateDB Protein IDBP-360606.4
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol DLGAP2
Protein Name discs, large (Drosophila) homolog-associated protein 2
Synonyms DAP2; SAPAP2;
Species Homo sapiens
Ensembl Protein ENSP00000400258
InnateDB Gene IDBG-5385 (DLGAP2)
Protein Structure
UniProt Annotation
Function May play a role in the molecular organization of synapses and neuronal cell signaling. Could be an adapter protein linking ion channel to the subsynaptic cytoskeleton. May induce enrichment of PSD-95/SAP90 at the plasma membrane.
Subcellular Localization Cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Cell junction, synapse, postsynaptic cell membrane, postsynaptic density {ECO:0000250}. Cell junction, synapse {ECO:0000250}. Note=Postsynaptic density of neuronal cells. {ECO:0000250}.
Disease Associations
Tissue Specificity Expressed in brain and kidney.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
Experimentally validated
Total 5 [view]
Protein-Protein 5 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0007267 cell-cell signaling
GO:0007270 neuron-neuron synaptic transmission
Cellular Component
GO:0005883 neurofilament
GO:0014069 postsynaptic density
GO:0030054 cell junction
GO:0045211 postsynaptic membrane
Protein Structure and Domains
PDB ID
InterPro IPR005026 Guanylate-kinase-associated protein
PFAM PF03359
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9P1A6
PhosphoSite PhosphoSite-Q9P1A6
TrEMBL
UniProt Splice Variant
Entrez Gene 9228
UniGene Hs.603990
RefSeq NP_004736
HUGO HGNC:2906
OMIM 605438
CCDS CCDS47760
HPRD 09258
IMGT
EMBL AB000275 AC026950 AC100797 AC110288 AF009204 AF119817 AF119818 BC141862 CH471181
GenPept AAB71661 AAF34344 AAF34345 AAI41863 BAA23256 EAW51474 EAW51475

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca