InnateDB Protein
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IDBP-360763.4
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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SLC6A12
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Protein Name
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solute carrier family 6 (neurotransmitter transporter, betaine/GABA), member 12
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Synonyms
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BGT-1; BGT1; GAT2;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000399136
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InnateDB Gene
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IDBG-11214 (SLC6A12)
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Protein Structure
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Function |
Transports betaine and GABA. May have a role in regulation of GABAergic transmission in the brain through the reuptake of GABA into presynaptic terminals, as well as in osmotic regulation.
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Subcellular Localization |
Membrane; Multi-pass membrane protein.
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Disease Associations |
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Tissue Specificity |
Liver, heart, skeletal muscle, placenta, and a widespread distribution in the brain.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
2
[view]
|
Protein-Protein |
1
[view]
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Protein-DNA |
1
[view]
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
Accession |
GO Term |
GO:0005328
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neurotransmitter:sodium symporter activity
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GO:0005332
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gamma-aminobutyric acid:sodium symporter activity
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR000175
Sodium:neurotransmitter symporter
IPR002983
Sodium:neurotransmitter symporter, betaine
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PFAM |
PF00209
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PRINTS |
PR00176
PR01198
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
P48065
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PhosphoSite |
PhosphoSite-
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TrEMBL |
F5H2T6
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UniProt Splice Variant |
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Entrez Gene |
6539
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UniGene |
Hs.437174
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RefSeq |
NP_003035
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HUGO |
HGNC:11045
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OMIM |
603080
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CCDS |
CCDS8501
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HPRD |
04358
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IMGT |
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EMBL |
AC007406
AK096046
AK313690
BC126215
BC126217
CH471116
L42300
U27699
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GenPept |
AAA66574
AAA87029
AAI26216
AAI26218
BAG36439
BAG53203
EAW88975
EAW88976
EAW88977
EAW88978
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