InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: TNIP3

Summary

InnateDB Protein

IDBP-36078.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TNIP3

Protein Name

TNFAIP3 interacting protein 3

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000057513

InnateDB Gene

IDBG-36076 (TNIP3)

Protein Structure

UniProt Annotation

Function

Binds to zinc finger protein TNFAIP3 and inhibits NF- kappa-B activation induced by tumor necrosis factor, Toll-like receptor 4 (TLR4), interleukin-1 and 12-O-tetradecanoylphorbol-13- acetate. Overexpression inhibits NF-kappa-B-dependent gene expression in response to lipopolysaccharide at a level downstream of TRAF6 and upstream of IKBKB. NF-kappa-B inhibition is independent of TNFAIP3 binding. {ECO:0000269PubMed:17088249}.

Subcellular Localization

Disease Associations

Tissue Specificity

Highly expressed in lung, lymph node, thymus and fetal liver. Expressed at lower levels in bone marrow, brain, kidney, spleen, leukocytes and tonsils. Could be detected in heart, salivary gland, adrenal gland, pancreas, ovary and fetal brain. High levels detected in liver, colon, small intestine, muscle, stomach, testis, placenta, thyroid, uterus, prostate, skin and PBL. {ECO:0000269PubMed:11345586, ECO:0000269PubMed:17088249}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	6 [view]
Protein-Protein	5 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0031593	polyubiquitin binding

Biological Process

GO:0002756	MyD88-independent toll-like receptor signaling pathway
GO:0006954	inflammatory response
GO:0034142	toll-like receptor 4 signaling pathway
GO:0043124	negative regulation of I-kappaB kinase/NF-kappaB signaling
GO:0045087	innate immune response (InnateDB)
GO:0071222	cellular response to lipopolysaccharide