InnateDB Protein
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IDBP-360781.5
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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SLBP
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Protein Name
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stem-loop binding protein
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Synonyms
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HBP;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000406322
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InnateDB Gene
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IDBG-6789 (SLBP)
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Protein Structure
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Function |
RNA-binding protein involved in the histone pre-mRNA processing. Binds the stem-loop structure of replication-dependent histone pre-mRNAs and contributes to efficient 3'-end processing by stabilizing the complex between histone pre-mRNA and U7 small nuclear ribonucleoprotein (snRNP), via the histone downstream element (HDE). Plays an important role in targeting mature histone mRNA from the nucleus to the cytoplasm and to the translation machinery. Stabilizes mature histone mRNA and could be involved in cell-cycle regulation of histone gene expression. Involved in the mechanism by which growing oocytes accumulate histone proteins that support early embryogenesis. Binds to the 5' side of the stem-loop structure of histone pre-mRNAs. {ECO:0000269PubMed:12588979, ECO:0000269PubMed:19155325}.
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Subcellular Localization |
Cytoplasm. Nucleus. Note=Polyribosome- associated. Localizes predominantly in the nucleus at the G1/G2 phases and the beginning of S phase. Through the S phase, partially redistributes to the cytoplasm. Binding to histone mRNA is necessary for cytoplasmic localization. Shuttles between the nucleus and the cytoplasm. Imported in the nucleus by the Importin alpha/Importin beta receptor.
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Disease Associations |
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Tissue Specificity |
Widely expressed.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
8
[view]
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Protein-Protein |
8
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
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PFAM |
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q14493
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PhosphoSite |
PhosphoSite-Q14493
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TrEMBL |
B3KSC5
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UniProt Splice Variant |
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Entrez Gene |
7884
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UniGene |
Hs.599008
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RefSeq |
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HUGO |
HGNC:10904
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OMIM |
602422
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CCDS |
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HPRD |
03884
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IMGT |
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EMBL |
AC016773
AK091735
AK093314
BC014908
BC015703
CH471131
M63544
U75679
Z71188
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GenPept |
AAB97091
AAH14908
AAH15703
BAG52407
BAG52687
CAA94918
EAW82579
EAW82580
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