InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: SLBP

Summary

InnateDB Gene

IDBG-6789.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SLBP

Gene Name

stem-loop binding protein

Synonyms

HBP

Species

Homo sapiens

Ensembl Gene

ENSG00000163950

Encoded Proteins

IDBP-6791

stem-loop binding protein

IDBP-360781

stem-loop binding protein

IDBP-479479

stem-loop binding protein

IDBP-476624

stem-loop binding protein

IDBP-474806

stem-loop binding protein

IDBP-481058

stem-loop binding protein

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes a protein that binds to the stem-loop structure in replication-dependent histone mRNAs. Histone mRNAs do not contain introns or polyadenylation signals, and are processed by endonucleolytic cleavage. The stem-loop structure is essential for efficient processing but this structure also controls the transport, translation and stability of histone mRNAs. Expression of the protein is regulated during the cell cycle, increasing more than 10-fold during the latter part of G1. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 4:1692800-1712555

Strand

Reverse strand

Band

p16.3

Transcripts

ENST00000318386	ENSP00000316490
ENST00000429429	ENSP00000406322
ENST00000489418	ENSP00000417686
ENST00000483348	ENSP00000426891
ENST00000488267	ENSP00000418658
ENST00000480936	ENSP00000417359

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.

Experimentally validated
Total	8 [view]
Protein-Protein	8 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003729	mRNA binding
GO:0005515	protein binding
GO:0044822	poly(A) RNA binding
GO:0071207	histone pre-mRNA stem-loop binding
GO:0071208	histone pre-mRNA DCP binding

Biological Process

GO:0006366	transcription from RNA polymerase II promoter
GO:0006369	termination of RNA polymerase II transcription
GO:0006398	histone mRNA 3'-end processing
GO:0006406	mRNA export from nucleus
GO:0008334	histone mRNA metabolic process
GO:0010467	gene expression
GO:0031124	mRNA 3'-end processing
GO:0033260	nuclear cell cycle DNA replication
GO:0051028	mRNA transport

Cellular Component

GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0030529	ribonucleoprotein complex
GO:0071204	histone pre-mRNA 3'end processing complex