InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: NRCAM

Summary

InnateDB Protein

IDBP-36085.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

NRCAM

Protein Name

neuronal cell adhesion molecule

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000368314

InnateDB Gene

IDBG-36081 (NRCAM)

Protein Structure

UniProt Annotation

Function

Cell adhesion, ankyrin-binding protein involved in neuron-neuron adhesion. May play a role in the molecular assembly of the nodes of Ranvier (By similarity). {ECO:0000250}.

Subcellular Localization

Cell membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.

Disease Associations

Tissue Specificity

Detected in all the examined tissues. In the brain it was detected in the amygdala, caudate nucleus, corpus callosum, hippocampus, hypothalamus, substantia nigra, subthalamic nucleus and thalamus.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	9 [view]
Protein-Protein	8 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0030506	ankyrin binding
GO:0086080	protein binding involved in heterotypic cell-cell adhesion

Biological Process

GO:0001525	angiogenesis
GO:0001764	neuron migration
GO:0007409	axonogenesis
GO:0007411	axon guidance
GO:0007413	axonal fasciculation
GO:0007416	synapse assembly
GO:0007417	central nervous system development
GO:0008104	protein localization
GO:0010975	regulation of neuron projection development
GO:0016337	single organismal cell-cell adhesion
GO:0019227	neuronal action potential propagation
GO:0030516	regulation of axon extension
GO:0031290	retinal ganglion cell axon guidance
GO:0034113	heterotypic cell-cell adhesion
GO:0045162	clustering of voltage-gated sodium channels
GO:0045666	positive regulation of neuron differentiation

Cellular Component

GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0009897	external side of plasma membrane
GO:0030424	axon
GO:0043005	neuron projection
GO:0043194	axon initial segment
GO:0045202	synapse

Protein Structure and Domains

PDB ID

InterPro

IPR003598 Immunoglobulin subtype 2
IPR003599 Immunoglobulin subtype
IPR003961 Fibronectin, type III
IPR007110 Immunoglobulin-like domain
IPR013098 Immunoglobulin I-set
IPR013151 Immunoglobulin

PFAM

PF00041
PF01108
PF07679
PF00047

PRINTS

PIRSF

SMART

SM00408
SM00409
SM00060

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q92823