Version 5.4
Homo sapiens Gene: NRCAM
Summary
InnateDB Gene IDBG-36081.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol NRCAM
Gene Name neuronal cell adhesion molecule
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000091129
Encoded Proteins
IDBP-36085
neuronal cell adhesion molecule
IDBP-36089
neuronal cell adhesion molecule
IDBP-36091
neuronal cell adhesion molecule
IDBP-36093
neuronal cell adhesion molecule
IDBP-385171
neuronal cell adhesion molecule
IDBP-385173
neuronal cell adhesion molecule
IDBP-385180
neuronal cell adhesion molecule
IDBP-385182
neuronal cell adhesion molecule
IDBP-385183
neuronal cell adhesion molecule
IDBP-385184
neuronal cell adhesion molecule
IDBP-385186
neuronal cell adhesion molecule
IDBP-385187
neuronal cell adhesion molecule
IDBP-809946
neuronal cell adhesion molecule
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Cell adhesion molecules (CAMs) are members of the immunoglobulin superfamily. This gene encodes a neuronal cell adhesion molecule with multiple immunoglobulin-like C2-type domains and fibronectin type-III domains. This ankyrin-binding protein is involved in neuron-neuron adhesion and promotes directional signaling during axonal cone growth. This gene is also expressed in non-neural tissues and may play a general role in cell-cell communication via signaling from its intracellular domain to the actin cytoskeleton during directional cell migration. Allelic variants of this gene have been associated with autism and addiction vulnerability. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 7:108147623-108456717
Strand Reverse strand
Band q31.1
Transcripts
ENST00000379028 ENSP00000368314
ENST00000351718 ENSP00000325269
ENST00000379024 ENSP00000368310
ENST00000379022 ENSP00000368308
ENST00000425651 ENSP00000401244
ENST00000445634 ENSP00000398174
ENST00000415105
ENST00000417701 ENSP00000390421
ENST00000442580 ENSP00000390868
ENST00000456431 ENSP00000408203
ENST00000419936 ENSP00000397544
ENST00000413765 ENSP00000407858
ENST00000418239 ENSP00000393663
ENST00000522550
ENST00000465585
ENST00000489800
ENST00000613830 ENSP00000484840
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 9 [view]
Protein-Protein 8 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0030506 ankyrin binding
GO:0086080 protein binding involved in heterotypic cell-cell adhesion
Biological Process
GO:0001525 angiogenesis
GO:0001764 neuron migration
GO:0007409 axonogenesis
GO:0007411 axon guidance
GO:0007413 axonal fasciculation
GO:0007416 synapse assembly
GO:0007417 central nervous system development
GO:0008104 protein localization
GO:0010975 regulation of neuron projection development
GO:0016337 single organismal cell-cell adhesion
GO:0019227 neuronal action potential propagation
GO:0030516 regulation of axon extension
GO:0031290 retinal ganglion cell axon guidance
GO:0034113 heterotypic cell-cell adhesion
GO:0045162 clustering of voltage-gated sodium channels
GO:0045666 positive regulation of neuron differentiation
Cellular Component
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0009897 external side of plasma membrane
GO:0030424 axon
GO:0043005 neuron projection
GO:0043194 axon initial segment
GO:0045202 synapse
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000020598
View Gene Order
ENSBTAG00000006732
Not yet available
Pathways
NETPATH
REACTOME
REACT_22312
Neurofascin interactions pathway
REACT_22329
NrCAM interactions pathway
REACT_22266
Interaction between L1 and Ankyrins pathway
REACT_22205
L1CAM interactions pathway
REACT_111045
Developmental Biology pathway
REACT_18266
Axon guidance pathway
KEGG
hsa04514
Cell adhesion molecules (CAMs) pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.713211
RefSeq NM_001037132 NM_001193582 NM_001193583 NM_001193584 NM_005010 XM_005250373 XM_005250383 XM_006716003 XM_006716004 XM_006716005 XM_006716012 XM_006716013
HUGO
OMIM
CCDS CCDS47686 CCDS55153 CCDS5751 CCDS75652
HPRD 07207
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca