InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: NAT8L

Summary

InnateDB Protein

IDBP-360947.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

NAT8L

Protein Name

N-acetyltransferase 8-like (GCN5-related, putative)

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000413064

InnateDB Gene

IDBG-7315 (NAT8L)

Protein Structure

UniProt Annotation

Function

Plays a role in the regulation of lipogenesis by producing N-acetylaspartate acid (NAA), a brain-specific metabolite. NAA occurs in high concentration in brain and its hydrolysis plays a significant part in the maintenance of intact white matter. Promotes dopamine uptake by regulating TNF-alpha expression. Attenuates methamphetamine-induced inhibition of dopamine uptake. {ECO:0000269PubMed:19524112}.

Subcellular Localization

Cytoplasm. Membrane {ECO:0000305}; Single- pass membrane protein {ECO:0000305}. Microsome membrane {ECO:0000250}; Single-pass membrane protein {ECO:0000250}. Mitochondrion membrane; Single-pass membrane protein. Rough endoplasmic reticulum membrane {ECO:0000250}; Single-pass membrane protein {ECO:0000250}. Note=Its enzymatic activity contribution is quantitatively larger in mitochondrial compartment than in extramitochondrial compartment.

Disease Associations

N-acetylaspartate deficiency (NACED) [MIM:614063]: A metabolic disorder resulting in truncal ataxia, marked developmental delay, seizures, and secondary microcephaly. {ECO:0000269PubMed:19807691}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Tissue Specificity

Expressed in brain. {ECO:0000269PubMed:19807691}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0008080	N-acetyltransferase activity
GO:0017188	aspartate N-acetyltransferase activity

Biological Process

GO:0008152	metabolic process
GO:0051586	positive regulation of dopamine uptake involved in synaptic transmission

Cellular Component

GO:0005737	cytoplasm
GO:0005789	endoplasmic reticulum membrane
GO:0016021	integral component of membrane
GO:0030867	rough endoplasmic reticulum membrane
GO:0031966	mitochondrial membrane