Version 5.4
Homo sapiens Gene: NAT8L
Summary
InnateDB Gene IDBG-7315.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol NAT8L
Gene Name N-acetyltransferase 8-like (GCN5-related, putative)
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000185818
Encoded Proteins
IDBP-7319
N-acetyltransferase 8-like (GCN5-related, putative)
IDBP-360947
N-acetyltransferase 8-like (GCN5-related, putative)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a single-pass membrane protein, which contains a conserved sequence of the GCN5 or NAT superfamily of N-acetyltransferases and is a member of the N-acyltransferase (NAT) superfamily. This protein is a neuron-specific protein and is the N-acetylaspartate (NAA) biosynthetic enzyme, catalyzing the NAA synthesis from L-aspartate and acetyl-CoA. NAA is a major storage and transport form of acetyl coenzyme A specific to the nervous system. The gene mutation results in primary NAA deficiency (hypoacetylaspartia). [provided by RefSeq, Dec 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 4:2059512-2069089
Strand Forward strand
Band p16.3
Transcripts
ENST00000331662 ENSP00000328464
ENST00000423729 ENSP00000413064
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0008080 N-acetyltransferase activity
GO:0017188 aspartate N-acetyltransferase activity
Biological Process
GO:0008152 metabolic process
GO:0051586 positive regulation of dopamine uptake involved in synaptic transmission
Cellular Component
GO:0005737 cytoplasm
GO:0005789 endoplasmic reticulum membrane
GO:0016021 integral component of membrane
GO:0030867 rough endoplasmic reticulum membrane
GO:0031966 mitochondrial membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000048142
View Gene Order
ENSBTAG00000031364
Not yet available
Pathways
NETPATH
REACTOME
KEGG
hsa00250
Alanine, aspartate and glutamate metabolism pathway
INOH
PID NCI
Cross-References
SwissProt Q8N9F0
TrEMBL
UniProt Splice Variant
Entrez Gene 339983
UniGene Hs.318529
RefSeq NM_178557 XM_006710156
HUGO HGNC:26742
OMIM 610647
CCDS CCDS3359
HPRD
IMGT
EMBL AK094797 AL132868 BC093906 BC093908 BC103748 CN256164
GenPept AAH93906 AAH93908 AAI03749 BAC04426 CAM15218
RNA Seq Atlas 339983

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca