Version 5.4
| Homo sapiens Protein: MUC6 | |||||||||
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| Summary | |||||||||
| InnateDB Protein | IDBP-361023.4 | ||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||
| Gene Symbol | MUC6 | ||||||||
| Protein Name | mucin 6, oligomeric mucus/gel-forming | ||||||||
| Synonyms | MUC-6; | ||||||||
| Species | Homo sapiens | ||||||||
| Ensembl Protein | ENSP00000406861 | ||||||||
| InnateDB Gene | IDBG-18722 (MUC6) | ||||||||
| Protein Structure |
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| UniProt Annotation | |||||||||
| Function | May provide a mechanism for modulation of the composition of the protective mucus layer related to acid secretion or the presence of bacteria and noxious agents in the lumen. Plays an important role in the cytoprotection of epithelial surfaces and are used as tumor markers in a variety of cancers. May play a role in epithelial organogenesis. {ECO:0000269PubMed:10209489, ECO:0000269PubMed:10330458, ECO:0000269PubMed:11988092}. | ||||||||
| Subcellular Localization | Secreted. | ||||||||
| Disease Associations | |||||||||
| Tissue Specificity | Expressed in the regenerative zone of gastric antrum, gastric body mucosa and gastric incisura mucosa. Expressed in the deeper mucous glands of gastric antrum. Overexpressed in Helicobacter pylori infected gastric epithelium. Highly expressed in duodenal Brunner's glands, gall bladder, seminal vesicle, pancreatic centroacinar cells and ducts, and periductal glands of the common bile duct. {ECO:0000269PubMed:10209489, ECO:0000269PubMed:10330458, ECO:0000269PubMed:11988092, ECO:0000269PubMed:15280409, ECO:0000269PubMed:9422745}. | ||||||||
| Comments | |||||||||
| Interactions | |||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
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| Gene Ontology | |||||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Protein Structure and Domains | |||||||||
| PDB ID | |||||||||
| InterPro |
IPR001846
von Willebrand factor, type D domain IPR002919 Trypsin Inhibitor-like, cysteine rich domain IPR006207 Cystine knot, C-terminal IPR006552 VWC out IPR014853 Uncharacterised domain, cysteine-rich |
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| PFAM |
PF00094
PF01826 PF08742 |
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| PRINTS | |||||||||
| PIRSF | |||||||||
| SMART |
SM00216
SM00041 SM00215 SM00832 |
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| TIGRFAMs | |||||||||
| Post-translational Modifications | |||||||||
| Modification | |||||||||
| Cross-References | |||||||||
| SwissProt | Q6W4X9 | ||||||||
| PhosphoSite | PhosphoSite-Q6W4X9 | ||||||||
| TrEMBL | Q6W3D1 | ||||||||
| UniProt Splice Variant | |||||||||
| Entrez Gene | 4588 | ||||||||
| UniGene | Hs.703727 | ||||||||
| RefSeq | NP_005952 | ||||||||
| HUGO | HGNC:7517 | ||||||||
| OMIM | 158374 | ||||||||
| CCDS | CCDS44513 | ||||||||
| HPRD | |||||||||
| IMGT | |||||||||
| EMBL | AC139749 AK092533 AK096772 AY312160 AY314024 AY458429 AY500284 JQ511950 JQ511951 JQ511952 JQ511953 L07517 U97698 | ||||||||
| GenPept | AAA35866 AAC51370 AAQ82434 AAQ86940 AAS13634 AAS76674 AFG72983 AFG72984 AFG72985 AFG72986 BAC04860 | ||||||||