InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: EFNA5

Summary

InnateDB Protein

IDBP-36104.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

EFNA5

Protein Name

ephrin-A5

Synonyms

AF1; EFL5; EPLG7; GLC1M; LERK7; RAGS;

Species

Homo sapiens

Ensembl Protein

ENSP00000328777

InnateDB Gene

IDBG-36100 (EFNA5)

Protein Structure

UniProt Annotation

Function

Cell surface GPI-bound ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Induces compartmentalized signaling within a caveolae-like membrane microdomain when bound to the extracellular domain of its cognate receptor. This signaling event requires the activity of the Fyn tyrosine kinase. Activates the EPHA3 receptor to regulate cell-cell adhesion and cytoskeletal organization. With the receptor EPHA2 may regulate lens fiber cells shape and interactions and be important for lens transparency maintenance. May function actively to stimulate axon fasciculation. The interaction of EFNA5 with EPHA5 also mediates communication between pancreatic islet cells to regulate glucose-stimulated insulin secretion. Cognate/functional ligand for EPHA7, their interaction regulates brain development modulating cell-cell adhesion and repulsion. {ECO:0000269PubMed:10601038, ECO:0000269PubMed:11870224}.

Subcellular Localization

Cell membrane {ECO:0000269PubMed:11870224}; Lipid-anchor, GPI-anchor {ECO:0000269PubMed:11870224}. Membrane, caveola {ECO:0000269PubMed:11870224}; Lipid-anchor, GPI-anchor {ECO:0000269PubMed:11870224}. Note=Compartmentalized in discrete caveolae-like membrane microdomains.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 13 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	13 [view]
Protein-Protein	11 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0045499	chemorepellent activity
GO:0046875	ephrin receptor binding

Biological Process

GO:0007399	nervous system development
GO:0007411	axon guidance
GO:0022407	regulation of cell-cell adhesion
GO:0031290	retinal ganglion cell axon guidance
GO:0032314	regulation of Rac GTPase activity
GO:0032319	regulation of Rho GTPase activity
GO:0032956	regulation of actin cytoskeleton organization
GO:0048013	ephrin receptor signaling pathway
GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation
GO:0050919	negative chemotaxis
GO:0051893	regulation of focal adhesion assembly
GO:0061178	regulation of insulin secretion involved in cellular response to glucose stimulus
GO:0070507	regulation of microtubule cytoskeleton organization