InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CTSB

Summary

InnateDB Protein

IDBP-361122.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CTSB

Protein Name

cathepsin B

Synonyms

APPS; CPSB;

Species

Homo sapiens

Ensembl Protein

ENSP00000409917

InnateDB Gene

IDBG-7654 (CTSB)

Protein Structure

UniProt Annotation

Function

Thiol protease which is believed to participate in intracellular degradation and turnover of proteins. Has also been implicated in tumor invasion and metastasis.

Subcellular Localization

Lysosome. Melanosome. Secreted, extracellular space {ECO:0000250}. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 47 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	47 [view]
Protein-Protein	47 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004197	cysteine-type endopeptidase activity
GO:0005515	protein binding
GO:0005518	collagen binding
GO:0008233	peptidase activity
GO:0008234	cysteine-type peptidase activity
GO:0043394	proteoglycan binding

Biological Process

GO:0002224	toll-like receptor signaling pathway
GO:0006508	proteolysis
GO:0022617	extracellular matrix disassembly
GO:0030198	extracellular matrix organization
GO:0030574	collagen catabolic process
GO:0030855	epithelial cell differentiation
GO:0042981	regulation of apoptotic process
GO:0045087	innate immune response (InnateDB)
GO:0050790	regulation of catalytic activity
GO:0051603	proteolysis involved in cellular protein catabolic process
GO:0097067	cellular response to thyroid hormone stimulus

Cellular Component

GO:0005576	extracellular region
GO:0005615	extracellular space
GO:0005622	intracellular
GO:0005730	nucleolus
GO:0005764	lysosome
GO:0036021	endolysosome lumen
GO:0042470	melanosome
GO:0043231	intracellular membrane-bounded organelle
GO:0048471	perinuclear region of cytoplasm
GO:0070062	extracellular vesicular exosome