InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: CTSB

Summary

InnateDB Gene

IDBG-7654.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CTSB

Gene Name

cathepsin B

Synonyms

APPS; CPSB

Species

Homo sapiens

Ensembl Gene

ENSG00000164733

Encoded Proteins

IDBP-7656

cathepsin B

IDBP-7658

cathepsin B

IDBP-361122

cathepsin B

IDBP-594825

cathepsin B

IDBP-603565

cathepsin B

IDBP-589963

cathepsin B

IDBP-601081

cathepsin B

IDBP-583561

cathepsin B

IDBP-600229

cathepsin B

IDBP-812382

cathepsin B

IDBP-598052

cathepsin B

IDBP-598294

cathepsin B

IDBP-589669

cathepsin B

IDBP-597439

cathepsin B

IDBP-591135

cathepsin B

IDBP-601738

cathepsin B

IDBP-593875

cathepsin B

IDBP-584669

cathepsin B

IDBP-597437

cathepsin B

IDBP-592475

cathepsin B

IDBP-593449

cathepsin B

IDBP-599780

cathepsin B

IDBP-597114

cathepsin B

IDBP-586764

cathepsin B

IDBP-585934

cathepsin B

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation

Summary

PMID 18762176

CTSB is a member of the Cathepsins protein family which are key modulators of cell death and inflammatory responses.

PMID 21145045

CTSB is an endosomal and lysosomal protease that is upregulated during various inflammatory disorders. TLR2, 3, 4 ligand engagement increases the proteolytic activities of CTSB in macrophages without changing the mRNA expression or the endogenous inhibitors of CTSB. (Demonstrated in murine model)

InnateDB Annotation from Orthologs

Summary

PMID 21145045

[Mus musculus] Ctsb is an endosomal and lysosomal protease that is upregulated during various inflammatory disorders. Tlr2, 3, 4 ligand engagement increases the proteolytic activities of Ctsb in macrophages.

Entrez Gene

Summary

The protein encoded by this gene is a lysosomal cysteine proteinase composed of a dimer of disulfide-linked heavy and light chains, both produced from a single protein precursor. It is also known as amyloid precursor protein secretase and is involved in the proteolytic processing of amyloid precursor protein (APP). Incomplete proteolytic processing of APP has been suggested to be a causative factor in Alzheimer disease, the most common cause of dementia. Overexpression of the encoded protein, which is a member of the peptidase C1 family, has been associated with esophageal adenocarcinoma and other tumors. At least five transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 8:11842524-11869448

Strand

Reverse strand

Band

p23.1

Transcripts

ENST00000353047	ENSP00000345672
ENST00000345125	ENSP00000342070
ENST00000453527	ENSP00000409917
ENST00000420692
ENST00000505496	ENSP00000435650
ENST00000530640	ENSP00000435105
ENST00000531089	ENSP00000433215
ENST00000531551	ENSP00000436456
ENST00000533455	ENSP00000432244
ENST00000534510	ENSP00000434217
ENST00000526481	ENSP00000473301
ENST00000530624
ENST00000532409
ENST00000530290
ENST00000533110
ENST00000534636	ENSP00000436159
ENST00000533572	ENSP00000433995
ENST00000530296	ENSP00000435074
ENST00000525076
ENST00000526195	ENSP00000436627
ENST00000527243	ENSP00000434725
ENST00000534149	ENSP00000436122
ENST00000526645	ENSP00000431518
ENST00000525315
ENST00000532370
ENST00000524500	ENSP00000436074
ENST00000531502	ENSP00000435886
ENST00000527215	ENSP00000433379
ENST00000532656	ENSP00000431143
ENST00000534382	ENSP00000435260
ENST00000528965	ENSP00000433929
ENST00000524654	ENSP00000432077
ENST00000532392	ENSP00000432408

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 47 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	47 [view]
Protein-Protein	47 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004197	cysteine-type endopeptidase activity
GO:0005515	protein binding
GO:0005518	collagen binding
GO:0008233	peptidase activity
GO:0008234	cysteine-type peptidase activity
GO:0043394	proteoglycan binding

Biological Process

GO:0002224	toll-like receptor signaling pathway
GO:0006508	proteolysis
GO:0022617	extracellular matrix disassembly
GO:0030198	extracellular matrix organization
GO:0030574	collagen catabolic process
GO:0030855	epithelial cell differentiation
GO:0042981	regulation of apoptotic process
GO:0045087	innate immune response (InnateDB)
GO:0046697	decidualization
GO:0050790	regulation of catalytic activity
GO:0051603	proteolysis involved in cellular protein catabolic process
GO:0097067	cellular response to thyroid hormone stimulus

Cellular Component

GO:0005576	extracellular region
GO:0005615	extracellular space
GO:0005622	intracellular
GO:0005730	nucleolus
GO:0005739	mitochondrion
GO:0005764	lysosome
GO:0036021	endolysosome lumen
GO:0042470	melanosome
GO:0043231	intracellular membrane-bounded organelle
GO:0048471	perinuclear region of cytoplasm
GO:0070062	extracellular vesicular exosome