InnateDB Protein
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IDBP-361141.5
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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CDYL
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Protein Name
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chromodomain protein, Y-like
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Synonyms
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CDYL1;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000394076
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InnateDB Gene
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IDBG-58613 (CDYL)
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Protein Structure
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Function |
Acts as a RE1-silencing transcription factor (REST) corepressor that facilitates histone-lysine N-methyltransferase EHMT2 recruitment and H3K9 dimethylation at REST target genes for repression. Required for chromatin targeting and maximal enzymatic activity of polycomb repressive complex 2 (PRC2); acts as a positive regulator of PRC2 activity by bridging the pre-existing histone H3K27me3 and newly recruited PRC2 on neighboring nucleosomes. Has histone acetyltransferase activity, with a preference for histone H4. {ECO:0000269PubMed:12072557, ECO:0000269PubMed:19061646, ECO:0000269PubMed:22009739}.
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Subcellular Localization |
Nucleus {ECO:0000269PubMed:18450745, ECO:0000269PubMed:19808672}.
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Disease Associations |
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Tissue Specificity |
Ubiquitous. Expressed at moderate levels in all tissues examined. Isoform 2 is the most abundantly expressed isoform. {ECO:0000269PubMed:19808672}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 26 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
26
[view]
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Protein-Protein |
25
[view]
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Protein-DNA |
1
[view]
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR001753
Crotonase superfamily
IPR029045
ClpP/crotonase-like domain
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PFAM |
PF00378
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q9Y232
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PhosphoSite |
PhosphoSite-Q9Y232
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
9425
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UniGene |
Hs.705841
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RefSeq |
NP_001137442
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HUGO |
HGNC:1811
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OMIM |
603778
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CCDS |
CCDS47364
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HPRD |
04803
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IMGT |
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EMBL |
AF081258
AF081259
AK291601
AK296985
AL022725
AL050164
AL356747
AL359643
BC061516
BC108725
BC119682
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GenPept |
AAD22734
AAD22735
AAH61516
AAI08726
AAI19683
BAF84290
BAG59526
CAB43304
CAC36888
CAH73737
CAI20892
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