InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: OGG1

Summary

InnateDB Protein

IDBP-361734.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

OGG1

Protein Name

8-oxoguanine DNA glycosylase

Synonyms

HMMH; HOGG1; MUTM; OGH1;

Species

Homo sapiens

Ensembl Protein

ENSP00000403598

InnateDB Gene

IDBG-15945 (OGG1)

Protein Structure

UniProt Annotation

Function

DNA repair enzyme that incises DNA at 8-oxoG residues. Excises 7,8-dihydro-8-oxoguanine and 2,6-diamino-4-hydroxy-5-N- methylformamidopyrimidine (FAPY) from damaged DNA. Has a beta- lyase activity that nicks DNA 3' to the lesion.

Subcellular Localization

Nucleus, nucleoplasm {ECO:0000269PubMed:17148573}. Nucleus speckle {ECO:0000269PubMed:17148573}. Nucleus matrix {ECO:0000269PubMed:17148573}. Note=Together with APEX1 is recruited to nuclear speckles in UVA-irradiated cells.Isoform 1A: Nucleus.Isoform 2A: Mitochondrion.

Disease Associations

Renal cell carcinoma (RCC) [MIM:144700]: Renal cell carcinoma is a heterogeneous group of sporadic or hereditary carcinoma derived from cells of the proximal renal tubular epithelium. It is subclassified into clear cell renal carcinoma (non-papillary carcinoma), papillary renal cell carcinoma, chromophobe renal cell carcinoma, collecting duct carcinoma with medullary carcinoma of the kidney, and unclassified renal cell carcinoma. Clear cell renal cell carcinoma is the most common subtype. Note=The disease may be caused by mutations affecting the gene represented in this entry.

Tissue Specificity

Ubiquitous.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 15 experimentally validated interaction(s) in this database.

Experimentally validated
Total	15 [view]
Protein-Protein	12 [view]
Protein-DNA	3 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003684	damaged DNA binding
GO:0003824	catalytic activity
GO:0004519	endonuclease activity
GO:0005515	protein binding
GO:0008534	oxidized purine nucleobase lesion DNA N-glycosylase activity

Biological Process

GO:0000737	DNA catabolic process, endonucleolytic
GO:0006281	DNA repair
GO:0006284	base-excision repair
GO:0006285	base-excision repair, AP site formation
GO:0006289	nucleotide-excision repair
GO:0006355	regulation of transcription, DNA-templated
GO:0006979	response to oxidative stress
GO:0009314	response to radiation
GO:0033158	regulation of protein import into nucleus, translocation
GO:0045007	depurination
GO:0090305	nucleic acid phosphodiester bond hydrolysis