InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ADCYAP1

Summary

InnateDB Protein

IDBP-362077.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ADCYAP1

Protein Name

adenylate cyclase activating polypeptide 1 (pituitary)

Synonyms

PACAP;

Species

Homo sapiens

Ensembl Protein

ENSP00000411658

InnateDB Gene

IDBG-368 (ADCYAP1)

Protein Structure

UniProt Annotation

Function

Binding to its receptor activates G proteins and stimulates adenylate cyclase in pituitary cells. Promotes neuron projection development through the RAPGEF2/Rap1/B-Raf/ERK pathway. {ECO:0000269PubMed:11175907, ECO:0000269PubMed:23800469}.

Subcellular Localization

Secreted.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	7 [view]
Protein-Protein	7 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005102	receptor binding
GO:0005179	hormone activity
GO:0005184	neuropeptide hormone activity
GO:0016521	pituitary adenylate cyclase activating polypeptide activity
GO:0051428	peptide hormone receptor binding

Biological Process

GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway
GO:0007190	activation of adenylate cyclase activity
GO:0007218	neuropeptide signaling pathway
GO:0007267	cell-cell signaling
GO:0007565	female pregnancy
GO:0008277	regulation of G-protein coupled receptor protein signaling pathway
GO:0010579	positive regulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathway
GO:0019933	cAMP-mediated signaling
GO:0031175	neuron projection development
GO:0032854	positive regulation of Rap GTPase activity
GO:0032880	regulation of protein localization
GO:0045860	positive regulation of protein kinase activity
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0048011	neurotrophin TRK receptor signaling pathway
GO:0070374	positive regulation of ERK1 and ERK2 cascade