InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: ADCYAP1

Summary

InnateDB Gene

IDBG-368.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ADCYAP1

Gene Name

adenylate cyclase activating polypeptide 1 (pituitary)

Synonyms

PACAP

Species

Homo sapiens

Ensembl Gene

ENSG00000141433

Encoded Proteins

IDBP-362077

adenylate cyclase activating polypeptide 1 (pituitary)

IDBP-725900

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes a secreted proprotein that is further processed into multiple mature peptides. These peptides stimulate adenylate cyclase and increase cyclic adenosine monophosphate (cAMP) levels, resulting in the transcriptional activation of target genes. The products of this gene are key mediators of neuroendocrine stress responses. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2013]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 18:904943-912172

Strand

Forward strand

Band

p11.32

Transcripts

ENST00000269200
ENST00000450565	ENSP00000411658
ENST00000579794	ENSP00000462647
ENST00000581602

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	7 [view]
Protein-Protein	7 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005057	receptor signaling protein activity
GO:0005102	receptor binding
GO:0005179	hormone activity
GO:0005184	neuropeptide hormone activity
GO:0016521	pituitary adenylate cyclase activating polypeptide activity
GO:0031858	pituitary adenylate cyclase-activating polypeptide receptor binding
GO:0051428	peptide hormone receptor binding

Biological Process

GO:0001541	ovarian follicle development
GO:0001662	behavioral fear response
GO:0001821	histamine secretion
GO:0002865	negative regulation of acute inflammatory response to antigenic stimulus
GO:0002878	negative regulation of acute inflammatory response to non-antigenic stimulus
GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway
GO:0007190	activation of adenylate cyclase activity
GO:0007204	positive regulation of cytosolic calcium ion concentration
GO:0007218	neuropeptide signaling pathway
GO:0007267	cell-cell signaling
GO:0007565	female pregnancy
GO:0008277	regulation of G-protein coupled receptor protein signaling pathway
GO:0008284	positive regulation of cell proliferation
GO:0010579	positive regulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathway
GO:0010628	positive regulation of gene expression
GO:0010656	negative regulation of muscle cell apoptotic process
GO:0010976	positive regulation of neuron projection development
GO:0019233	sensory perception of pain
GO:0019933	cAMP-mediated signaling
GO:0021983	pituitary gland development
GO:0030819	positive regulation of cAMP biosynthetic process
GO:0031175	neuron projection development
GO:0032755	positive regulation of interleukin-6 production
GO:0032854	positive regulation of Rap GTPase activity
GO:0032880	regulation of protein localization
GO:0034259	negative regulation of Rho GTPase activity
GO:0042594	response to starvation
GO:0043267	negative regulation of potassium ion transport
GO:0045471	response to ethanol
GO:0045786	negative regulation of cell cycle
GO:0045860	positive regulation of protein kinase activity
GO:0045909	positive regulation of vasodilation
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0046034	ATP metabolic process
GO:0048011	neurotrophin TRK receptor signaling pathway
GO:0051968	positive regulation of synaptic transmission, glutamatergic
GO:0060078	regulation of postsynaptic membrane potential
GO:0060124	positive regulation of growth hormone secretion
GO:0060253	negative regulation of glial cell proliferation
GO:0070374	positive regulation of ERK1 and ERK2 cascade
GO:0070445	regulation of oligodendrocyte progenitor proliferation
GO:0071385	cellular response to glucocorticoid stimulus
GO:0090274	positive regulation of somatostatin secretion