InnateDB Protein
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IDBP-36230.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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GAS2
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Protein Name
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growth arrest-specific 2
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000278187
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InnateDB Gene
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IDBG-36228 (GAS2)
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Protein Structure
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Function |
May play a role in apoptosis by acting as a cell death substrate for caspases. Is cleaved during apoptosis and the cleaved form induces dramatic rearrangements of the actin cytoskeleton and potent changes in the shape of the affected cells. May be involved in the membrane ruffling process (By similarity). {ECO:0000250}.
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Subcellular Localization |
Cytoplasm, cytoskeleton {ECO:0000250}. Membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Note=Component of the microfilament system. Colocalizes with actin fibers at the cell border and along the stress fibers in growth- arrested fibroblasts. Mainly membrane-associated. When hyperphosphorylated, accumulates at membrane ruffles (By similarity). {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
Ubiquitously expressed with highest levels in liver, lung, and kidney. Not found in spleen.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
2
[view]
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Protein-Protein |
2
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR001715
Calponin homology domain
IPR003108
Growth-arrest-specific protein 2 domain
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PFAM |
PF00307
PF02187
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PRINTS |
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PIRSF |
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SMART |
SM00033
SM00243
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TIGRFAMs |
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Modification |
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SwissProt |
O43903
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PhosphoSite |
PhosphoSite-O43903
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TrEMBL |
E9PRR5
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UniProt Splice Variant |
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Entrez Gene |
2620
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UniGene |
Hs.741320
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RefSeq |
NP_808221
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HUGO |
HGNC:4167
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OMIM |
602835
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CCDS |
CCDS7858
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HPRD |
04158
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IMGT |
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EMBL |
AC006299
AC103801
AK313734
BC013326
BC040470
CH471064
CR450285
U95032
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GenPept |
AAC52058
AAH13326
AAH40470
BAG36475
CAG29281
EAW68317
EAW68318
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