Version 5.4
Homo sapiens Gene: GAS2
Summary
InnateDB Gene IDBG-36228.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol GAS2
Gene Name growth arrest-specific 2
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000148935
Encoded Proteins
IDBP-36230
growth arrest-specific 2
IDBP-369691
growth arrest-specific 2
IDBP-597227
growth arrest-specific 2
IDBP-600485
growth arrest-specific 2
IDBP-594601
growth arrest-specific 2
IDBP-596631
growth arrest-specific 2
IDBP-598925
growth arrest-specific 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is a caspase-3 substrate that plays a role in regulating microfilament and cell shape changes during apoptosis. It can also modulate cell susceptibility to p53-dependent apoptosis by inhibiting calpain activity. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Jan 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:22625642-22813055
Strand Forward strand
Band p14.3
Transcripts
ENST00000278187 ENSP00000278187
ENST00000454584 ENSP00000401145
ENST00000528582 ENSP00000432584
ENST00000533092
ENST00000533363 ENSP00000434478
ENST00000524701 ENSP00000432026
ENST00000534801 ENSP00000433182
ENST00000532398 ENSP00000435946
ENST00000526665
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0006915 apoptotic process
GO:0006921 cellular component disassembly involved in execution phase of apoptosis
GO:0007050 cell cycle arrest
GO:0008360 regulation of cell shape
Cellular Component
GO:0005829 cytosol
GO:0005884 actin filament
GO:0016020 membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000030498
View Gene Order
ENSBTAG00000021654
Not yet available
Pathways
NETPATH
REACTOME
REACT_13541
Caspase-mediated cleavage of cytoskeletal proteins pathway
REACT_107
Apoptotic cleavage of cellular proteins pathway
REACT_995
Apoptotic execution phase pathway
REACT_578
Apoptosis pathway
KEGG
INOH
PID NCI
caspase_pathway
Caspase Cascade in Apoptosis
Cross-References
SwissProt O43903
TrEMBL E9PQ37
UniProt Splice Variant
Entrez Gene 2620
UniGene Hs.711297 Hs.741320
RefSeq NM_001143830 NM_005256 NM_177553
HUGO HGNC:4167
OMIM 602835
CCDS CCDS7858
HPRD 04158
IMGT
EMBL AC006299 AC103801 AK313734 BC013326 BC040470 CH471064 CR450285 U95032
GenPept AAC52058 AAH13326 AAH40470 BAG36475 CAG29281 EAW68317 EAW68318
RNA Seq Atlas 2620

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca