InnateDB Protein
|
IDBP-362367.4
|
Last Modified
|
2014-10-13 [Report errors or provide feedback]
|
Gene Symbol
|
CMPK2
|
Protein Name
|
cytidine monophosphate (UMP-CMP) kinase 2, mitochondrial
|
Synonyms
|
|
Species
|
Homo sapiens
|
Ensembl Protein
|
ENSP00000396385
|
InnateDB Gene
|
IDBG-26891 (CMPK2)
|
Protein Structure
|
|
Function |
May participate in dUTP and dCTP synthesis in mitochondria. Is able to phosphorylate dUMP, dCMP, CMP, UMP and monophosphates of the pyrimidine nucleoside analogs ddC, dFdC, araC, BVDU and FdUrd with ATP as phosphate donor. Efficacy is highest for dUMP followed by dCMP; CMP and UMP are poor substrates. May be involved in mtDNA depletion caused by long term treatment with ddC or other pyrimidine analogs. Also displays broad nucleoside diphosphate kinase activity. {ECO:0000269PubMed:17999954, ECO:0000269PubMed:23416111}.
|
Subcellular Localization |
Mitochondrion {ECO:0000269PubMed:17999954}.
|
Disease Associations |
|
Tissue Specificity |
Among all investigated tumors, leukemia cells show the most abundant expression. {ECO:0000269PubMed:17999954}.
|
Comments |
|
Number of Interactions
|
This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated |
Total |
1
[view]
|
Protein-Protein |
1
[view]
|
Protein-DNA |
0
|
Protein-RNA |
0
|
DNA-DNA |
0
|
RNA-RNA |
0
|
DNA-RNA |
0
|
|
Predicted by orthology |
Total |
3 [view]
|
|
|
Molecular Function |
|
Biological Process |
GO:0006165
|
nucleoside diphosphate phosphorylation
|
GO:0009142
|
nucleoside triphosphate biosynthetic process
|
|
Cellular Component |
|
PDB ID |
|
InterPro |
IPR014505
UMP-CMP kinase, mitochondrai
IPR027417
P-loop containing nucleoside triphosphate hydrolase
|
PFAM |
|
PRINTS |
|
PIRSF |
PIRSF019736
|
SMART |
|
TIGRFAMs |
|
Modification |
|
SwissProt |
Q5EBM0
|
PhosphoSite |
PhosphoSite-
|
TrEMBL |
I1Z9C7
|
UniProt Splice Variant |
|
Entrez Gene |
129607
|
UniGene |
Hs.7155
|
RefSeq |
NP_001243407
|
HUGO |
HGNC:27015
|
OMIM |
611787
|
CCDS |
CCDS58695
|
HPRD |
11233
|
IMGT |
|
EMBL |
AK127983
BC016969
BC089425
BC132821
BC141802
BC144202
JQ412833
|
GenPept |
AAH16969
AAH89425
AAI32822
AAI41803
AAI44203
AFJ19138
BAC87217
|
|
|