InnateDB Protein
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IDBP-362722.5
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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SRSF10
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Protein Name
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serine/arginine-rich splicing factor 10
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Synonyms
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FUSIP1; FUSIP2; NSSR; PPP1R149; SFRS13; SFRS13A; SRp38; SRrp40; TASR; TASR1; TASR2;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000388991
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InnateDB Gene
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IDBG-94079 (SRSF10)
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Protein Structure
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Function |
Splicing factor that in its dephosphorylated form acts as a general repressor of pre-mRNA splicing. Seems to interfere with the U1 snRNP 5'-splice recognition of SNRNP70. Required for splicing repression in M-phase cells and after heat shock. May be involved in regulation of alternative splicing in neurons, with isoform 1 acting as a positive and isoform 3 as a negative regulator. {ECO:0000269PubMed:11684676, ECO:0000269PubMed:12419250, ECO:0000269PubMed:14765198}.
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Subcellular Localization |
Nucleus speckle {ECO:0000269PubMed:11684676}. Cytoplasm {ECO:0000269PubMed:11684676}.
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Disease Associations |
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Tissue Specificity |
Widely expressed. {ECO:0000269PubMed:11684676, ECO:0000269PubMed:11891055}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 63 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated |
Total |
63
[view]
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Protein-Protein |
63
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
1 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR000504
RNA recognition motif domain
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PFAM |
PF00076
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PRINTS |
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PIRSF |
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SMART |
SM00360
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TIGRFAMs |
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Modification |
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SwissProt |
O75494
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PhosphoSite |
PhosphoSite-O75494
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
10772
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UniGene |
Hs.602683
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RefSeq |
NP_001177936
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HUGO |
HGNC:16713
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OMIM |
605221
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CCDS |
CCDS53281
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HPRD |
05562
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IMGT |
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EMBL |
AF047448
AF067730
AF419331
AF419332
AF449427
AK001286
AK001656
AK296175
AL590609
AY048592
AY150180
AY150181
BC001107
BC005039
BC010074
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GenPept |
AAC26727
AAC70918
AAH01107
AAH05039
AAH10074
AAL06098
AAL06099
AAL16665
AAL16666
AAL57514
AAN65380
AAN65381
BAA91601
BAG50956
BAG58911
CAI14803
CAI14805
CAI14807
CAI14808
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